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    CLEC18B C-type lectin domain family 18 member B [ Homo sapiens (human) ]

    Gene ID: 497190, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CLEC18Bprovided by HGNC
    Official Full Name
    C-type lectin domain family 18 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:33849
    See related
    Ensembl:ENSG00000140839 MIM:616572; AllianceGenome:HGNC:33849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRCL2
    Summary
    Predicted to enable polysaccharide binding activity. Predicted to be located in Golgi apparatus; endosome; and sarcoplasmic reticulum. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney (RPKM 34.8) and testis (RPKM 8.2) See more
    Orthologs
    all
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    Genomic context

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    Location:
    16q23.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (74408631..74424249, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (80223868..80242200, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (74442529..74456039, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:74414879-74415096 Neighboring gene nuclear pore complex interacting protein family member B15 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74431311-74432152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74433981-74434480 Neighboring gene uncharacterized LOC105376772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74441122-74442022 Neighboring gene uncharacterized LOC107984827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74465107-74465660 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:74496013-74497212 Neighboring gene RNA, U6 small nuclear 237, pseudogene Neighboring gene golgi glycoprotein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr16:74519761-74520313 Neighboring gene NANOG hESC enhancer GRCh37_chr16:74529259-74529934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74539585-74540084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74586439-74586940 Neighboring gene ribosomal protein S10 pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CLEC18B Associates With the Proliferation, Migration, and Prognosis of Glioblastoma. Guo RM, et al. ASN Neuro, 2018 Jan-Dec. PMID 29914265, Free PMC Article
    2. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. Huang YL, et al. J Biol Chem, 2015 Aug 28. PMID 26170455, Free PMC Article
    3. The C-type lectin-like domain superfamily. Zelensky AN, et al. FEBS J, 2005 Dec. PMID 16336259
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables polysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-type lectin domain family 18 member B
    Names
    mannose receptor-like 2
    mannose receptor-like protein 1
    secretory protein LOC497190

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011880.3 → NP_001011880.2  C-type lectin domain family 18 member B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001011880.2

      Status: VALIDATED

      Source sequence(s)
      AY358373, BM695392, DA374548, DA375446, DC309733
      Consensus CDS
      CCDS32484.1
      UniProtKB/Swiss-Prot
      B4DF90, Q6UXF7
      UniProtKB/TrEMBL
      F5H550
      Related
      ENSP00000341051.5, ENST00000339953.9
      Conserved Domains (2) summary
      cd00037
      Location:310 → 443
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:50 → 183
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    2. NM_001385192.1 → NP_001372121.1  C-type lectin domain family 18 member B isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009053
      Consensus CDS
      CCDS92195.1
      UniProtKB/TrEMBL
      A0A804HJ60, F5H550
      Conserved Domains (2) summary
      cd00037
      Location:310 → 434
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:50 → 183
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    3. NM_001385193.1 → NP_001372122.1  C-type lectin domain family 18 member B isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009053
      Consensus CDS
      CCDS92195.1
      UniProtKB/TrEMBL
      A0A804HJ60, F5H550
      Related
      ENSP00000507367.1, ENST00000682950.1
      Conserved Domains (2) summary
      cd00037
      Location:310 → 434
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:50 → 183
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    4. NM_001385194.1 → NP_001372123.1  C-type lectin domain family 18 member B isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009053
      UniProtKB/TrEMBL
      F8W692
      Conserved Domains (2) summary
      cd00037
      Location:230 → 354
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl00133
      Location:73 → 109
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    5. NM_001385195.1 → NP_001372124.1  C-type lectin domain family 18 member B isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC009053
      UniProtKB/TrEMBL
      F8W692
      Conserved Domains (2) summary
      cd00037
      Location:230 → 354
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl00133
      Location:73 → 109
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      74408631..74424249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434174.1 → XP_047290130.1  C-type lectin domain family 18 member B isoform X1

      UniProtKB/TrEMBL
      A0A804HJ60

    2. XM_047434173.1 → XP_047290129.1  C-type lectin domain family 18 member B isoform X1

      UniProtKB/TrEMBL
      A0A804HJ60

    3. XM_047434172.1 → XP_047290128.1  C-type lectin domain family 18 member B isoform X1

      UniProtKB/TrEMBL
      A0A804HJ60

    4. XM_047434176.1 → XP_047290132.1  C-type lectin domain family 18 member B isoform X1

      UniProtKB/TrEMBL
      A0A804HJ60

    5. XM_047434175.1 → XP_047290131.1  C-type lectin domain family 18 member B isoform X1

      UniProtKB/TrEMBL
      A0A804HJ60

    6. XM_047434177.1 → XP_047290133.1  C-type lectin domain family 18 member B isoform X2

    7. XM_047434178.1 → XP_047290134.1  C-type lectin domain family 18 member B isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      80223868..80242200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446631.1 → XP_047302587.1  C-type lectin domain family 18 member B isoform X4

    2. XM_047446638.1 → XP_047302594.1  C-type lectin domain family 18 member B isoform X10

    3. XM_047446632.1 → XP_047302588.1  C-type lectin domain family 18 member B isoform X5

    4. XM_047446633.1 → XP_047302589.1  C-type lectin domain family 18 member B isoform X6

    5. XM_047446630.1 → XP_047302586.1  C-type lectin domain family 18 member B isoform X4

    6. XM_047446629.1 → XP_047302585.1  C-type lectin domain family 18 member B isoform X4

    7. XM_047446639.1 → XP_047302595.1  C-type lectin domain family 18 member B isoform X11

    8. XM_047446637.1 → XP_047302593.1  C-type lectin domain family 18 member B isoform X1

    9. XM_047446636.1 → XP_047302592.1  C-type lectin domain family 18 member B isoform X9

    10. XM_047446635.1 → XP_047302591.1  C-type lectin domain family 18 member B isoform X8

    11. XM_047446634.1 → XP_047302590.1  C-type lectin domain family 18 member B isoform X7

    RNA

    1. XR_007086622.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXF7.2 GenPept UniProtKB/Swiss-Prot:Q6UXF7

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