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    PRSS51 serine protease 51 [ Homo sapiens (human) ]

    Gene ID: 346702, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PRSS51provided by HGNC
    Official Full Name
    serine protease 51provided by HGNC
    Primary source
    HGNC:HGNC:37321
    See related
    Ensembl:ENSG00000253649 AllianceGenome:HGNC:37321
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    8p23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (10481293..10547723, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9191405..9257428)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901887 Neighboring gene long intergenic non-protein coding RNA 3022 Neighboring gene RNA, U6 small nuclear 729, pseudogene Neighboring gene serine protease 52, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10382638-10383436 Neighboring gene serine protease 55 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10406483-10407477 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:10412556-10413270 Neighboring gene uncharacterized LOC105379237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10449944-10450820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10459109-10459704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10459705-10460299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10469845-10470570 Neighboring gene RP1 like 1 Neighboring gene MPRA-validated peak6901 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10489151-10489860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10493333-10494238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10494239-10495144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10503027-10503883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease-like protein 51
    Names
    protease, serine 51

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      10481293..10547723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422510.1 → XP_047278466.1  serine protease-like protein 51 isoform X2

    2. XM_047422509.1 → XP_047278465.1  serine protease-like protein 51 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ISV0
      Related
      ENSP00000497613.1, ENST00000647727.1

    RNA

    1. XR_007060820.1 RNA Sequence

    2. XR_007060819.1 RNA Sequence

    3. XR_007060818.1 RNA Sequence

    4. XR_007060817.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      2861848..2865294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007069084.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      9191405..9257428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445280.1 → XP_047301236.1  serine protease-like protein 51 isoform X2

    2. XM_047445278.1 → XP_047301234.1  serine protease-like protein 51 isoform X3

    3. XM_047445277.1 → XP_047301233.1  serine protease-like protein 51 isoform X1

    4. XM_047445279.1 → XP_047301235.1  serine protease-like protein 51 isoform X2

    RNA

    1. XR_007078693.1 RNA Sequence

    2. XR_007078691.1 RNA Sequence

    3. XR_007078689.1 RNA Sequence

    4. XR_007078690.1 RNA Sequence

    5. XR_007078692.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GVH4.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVH4

    Gene LinkOut

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