Cd59b CD59b antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd59bprovided by MGI
Official Full Name: CD59b antigenprovided by MGI
Primary source: MGI:MGI:1888996
See related: Ensembl:ENSMUSG00000068686 AllianceGenome:MGI:1888996
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable complement binding activity. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in cell surface and plasma membrane. Is expressed in blood; heart; liver; lung; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 6.6), subcutaneous fat pad adult (RPKM 5.9) and 24 other tissues See more
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Genomic context

Location:: 2 E2; 2 54.51 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103900127..103920619)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104069781..104085790)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E)
Title: Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.
mCd59ab(-/-) platelets are sensitive to complement-mediated activation and provide evidence for possible in vivo platelet activation in mCd59ab(-/-) mice.
Title: Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice.
Total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice.
Title: Generation and phenotyping of mCd59a and mCd59b double-knockout mice.
Expression of CD59b is present on mature spermatozoa and precursors and, in trace amounts, erythrocytes, and is likely only of relevance in the male reproductive system of mouse.
Title: CD59a is the primary regulator of membrane attack complex assembly in the mouse.
novel function in spermatogenesis that is most likely unrelated to its function as an inhibitor of membrane attack complex formation
Title: Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction.
Reported the mapping of promoter regions of both mouse Cd59a and Cd59b genes and identified that each Cd59 gene expresses two different tissue-specific transcripts that differ at their 5'ends.
Title: Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes.
Cd59b knockout mice present a phenotype characterized by hemolytic anemia, platelet activation and a progressive loss of fertility associated with immobile dysmorphic and fewer sperm cells after 5 months of age.
Title: Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.
Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b.
Title: Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

Cd59a (e-PCR), detects polymorphism
- UniSTS:547998

Cd59a (e-PCR), detects polymorphism
- UniSTS:547999

Cd59a (e-PCR), detects polymorphism
- UniSTS:548001

Cd59a (e-PCR), detects polymorphism
- UniSTS:548002

Cd59b (e-PCR), detects polymorphism
- UniSTS:548003

Rara (e-PCR), detects polymorphism
- UniSTS:144323

NoName (e-PCR)
- UniSTS:234477

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of activation of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of activation of membrane attack complex	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in compact myelin	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD59B glycoprotein

Names: MAC-IP; MAC-inhibitory protein; MACIF; membrane attack complex inhibition factor; protectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368215.1 → NP_001355144.1 CD59B glycoprotein precursor

Status: VALIDATED

Source sequence(s)

BX640578, BX813317

Consensus CDS

CCDS16486.1

UniProtKB/Swiss-Prot

P58019, Q920G7

Related

ENSMUSP00000106760.3, ENSMUST00000111130.3

Conserved Domains (1) summary

cd00117
Location:24 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
NM_181858.2 → NP_862906.1 CD59B glycoprotein precursor

See identical proteins and their annotated locations for NP_862906.1

Status: VALIDATED

Source sequence(s)

BX640578, BX813317

Consensus CDS

CCDS16486.1

UniProtKB/Swiss-Prot

P58019, Q920G7

Related

ENSMUSP00000087912.2, ENSMUST00000090429.8

Conserved Domains (1) summary

cd00117
Location:24 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

103900127..103920619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499802.5 → XP_006499865.1 CD59B glycoprotein isoform X4

See identical proteins and their annotated locations for XP_006499865.1

UniProtKB/Swiss-Prot

P58019, Q920G7

Related

ENSMUSP00000117553.2, ENSMUST00000129749.9

Conserved Domains (1) summary

cd00117
Location:24 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_006499805.2 → XP_006499868.1 CD59B glycoprotein isoform X4

See identical proteins and their annotated locations for XP_006499868.1

UniProtKB/Swiss-Prot

P58019, Q920G7

Conserved Domains (1) summary

cd00117
Location:24 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_006499801.3 → XP_006499864.1 CD59B glycoprotein isoform X2

Conserved Domains (1) summary

cd00117
Location:54 → 125

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_017319062.1 → XP_017174551.1 CD59B glycoprotein isoform X1

Conserved Domains (1) summary

cd00117
Location:67 → 138

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_036162337.1 → XP_036018230.1 CD59B glycoprotein isoform X3

Conserved Domains (1) summary

cl10471
Location:67 → 99

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_006499803.4 → XP_006499866.1 CD59B glycoprotein isoform X4

See identical proteins and their annotated locations for XP_006499866.1

UniProtKB/Swiss-Prot

P58019, Q920G7

Conserved Domains (1) summary

cd00117
Location:24 → 95

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...