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    Cspg5 chondroitin sulfate proteoglycan 5 [ Mus musculus (house mouse) ]

    Gene ID: 29873, updated on 12-May-2024

    Summary

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    Official Symbol
    Cspg5provided by MGI
    Official Full Name
    chondroitin sulfate proteoglycan 5provided by MGI
    Primary source
    MGI:MGI:1352747
    See related
    Ensembl:ENSMUSG00000032482 AllianceGenome:MGI:1352747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngc; Caleb
    Summary
    This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in frontal lobe adult (RPKM 51.3), cortex adult (RPKM 50.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110072851..110091644)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110243783..110262576)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene STARR-seq mESC enhancer starr_25255 Neighboring gene STARR-seq mESC enhancer starr_25257 Neighboring gene 4.5s RNA, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_25258 Neighboring gene predicted gene, 39429 Neighboring gene STARR-positive B cell enhancer ABC_E461 Neighboring gene microRNA 6236 Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C). Jüttner R, et al. Eur J Neurosci, 2013 Nov. PMID 23889129
    2. Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5. Cottet S, et al. Mol Vis, 2013. PMID 24265546, Free PMC Article
    3. Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice. Escher P, et al. Mol Vis, 2008. PMID 19050768, Free PMC Article
    4. The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. Brandt N, et al. EMBO J, 2007 May 2. PMID 17431398, Free PMC Article
    5. Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C. Aono S, et al. J Biol Chem, 2004 Nov 5. PMID 15331613

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CALEB is transiently required for synapse maturation in the cerebellum.
      Title: Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C).
    2. Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified.
      Title: Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5.
    3. During retinal degeneration in Rpe65-/- mice, neuroglycan C(NGC) expression is induced in neural retina, but not in retinal pigment epithelium, where NGC is expressed at highest levels.
      Title: Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice.
    4. PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
      Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
    5. there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
      Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
    6. phosphorylation and localization in lipid rafts
      Title: Phosphorylation of neuroglycan C, a brain-specific transmembrane chondroitin sulfate proteoglycan, and its localization in the lipid rafts.
    7. neuroglycan C is a novel component of midkine receptors involved in process elongation
      Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glial cell projection elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate proteoglycan 5
    Names
    acidic leucine-rich EGF-like domain-containing brain protein
    neuroglycan C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166273.1 → NP_001159745.1  chondroitin sulfate proteoglycan 5 isoform b precursor

      See identical proteins and their annotated locations for NP_001159745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform b), compared to isoform a. Isoform b is also known as NGC-III and mCALEBb. Variant 2 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.
      Source sequence(s)
      AC159372, AF461092, BC055736
      Consensus CDS
      CCDS52936.1
      UniProtKB/Swiss-Prot
      E9QN54, Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32
      Related
      ENSMUSP00000035058.6, ENSMUST00000035058.10
      Conserved Domains (2) summary
      pfam06566
      Location:33 → 273
      Chon_Sulph_att; Chondroitin sulphate attachment domain
      pfam06567
      Location:447 → 565
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

    2. NM_013884.3 → NP_038912.3  chondroitin sulfate proteoglycan 5 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a), also known as NGC-I and mCALEBa. Variant 1 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.
      Source sequence(s)
      AC159372, AF133700, AF461090, BC055736
      Consensus CDS
      CCDS81085.1
      UniProtKB/Swiss-Prot
      Q71M36
      Related
      ENSMUSP00000143164.2, ENSMUST00000196060.5
      Conserved Domains (2) summary
      pfam06566
      Location:33 → 273
      Chon_Sulph_att; Chondroitin sulphate attachment domain
      pfam06567
      Location:447 → 538
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110072851..110091644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71M36.2 GenPept UniProtKB/Swiss-Prot:Q71M36

    Gene LinkOut

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