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    Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

    Gene ID: 276770, updated on 9-May-2024

    Summary

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    Official Symbol
    Eif5aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by MGI
    Primary source
    MGI:MGI:106248
    See related
    Ensembl:ENSMUSG00000078812 AllianceGenome:MGI:106248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; eIF-5A-1; D19Wsu54e
    Summary
    This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69807538..69812784, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69916712..69921958, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5243 Neighboring gene G protein pathway suppressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Puleston DJ, et al. Cell Metab, 2019 Aug 6. PMID 31130465, Free PMC Article
    2. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. Maier B, et al. J Clin Invest, 2010 Jun. PMID 20501948, Free PMC Article
    3. Independent roles of eIF5A and polyamines in cell proliferation. Nishimura K, et al. Biochem J, 2005 Feb 1. PMID 15377278, Free PMC Article
    4. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Schultz CR, et al. Biol Open, 2023 Mar 15. PMID 36848144, Free PMC Article
    5. Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development. Nishimura K, et al. Amino Acids, 2012 Feb. PMID 21850436, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
      Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
    2. Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
      Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
    3. Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
      Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
    4. Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
      Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
    5. Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
      Title: Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
    6. The eIF5A (eIF5A(H)) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS).
      Title: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
    7. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
      Title: Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
    8. our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals
      Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
    9. knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development
      Title: Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
    10. These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation.
      Title: Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6725

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5A-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166589.1 → NP_001160061.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000047008.4, ENSMUST00000043419.10
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    2. NM_001166590.1 → NP_001160062.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000104250.2, ENSMUST00000108610.8
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    3. NM_001166591.1 → NP_001160063.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160063.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000067077.5, ENSMUST00000070996.11
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    4. NM_001166592.1 → NP_001160064.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000104251.2, ENSMUST00000108611.8
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    5. NM_001166593.1 → NP_001160065.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160065.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000068651.4, ENSMUST00000071026.10
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    6. NM_001166594.1 → NP_001160066.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000104252.2, ENSMUST00000108612.8
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    7. NM_001166595.1 → NP_001160067.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    8. NM_001166596.1 → NP_001160068.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000132717.2, ENSMUST00000164359.8
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    9. NM_181582.4 → NP_853613.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_853613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000104253.4, ENSMUST00000108613.10
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69807538..69812784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246050.2 → XP_030101910.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    2. XM_011249058.4 → XP_011247360.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011247360.1

      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Related
      ENSMUSP00000104249.2, ENSMUST00000108609.8
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    3. XM_030246051.1 → XP_030101911.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    4. XM_036156739.1 → XP_036012632.1  eukaryotic translation initiation factor 5A-1 isoform X1

      UniProtKB/Swiss-Prot
      P63242, Q5NCX0, Q78NR3
      UniProtKB/TrEMBL
      A0A0A0MQM0
      Conserved Domains (1) summary
      cl30809
      Location:1 → 150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63242.2 GenPept UniProtKB/Swiss-Prot:P63242

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