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    TIPARP TCDD inducible poly(ADP-ribose) polymerase [ Homo sapiens (human) ]

    Gene ID: 25976, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TIPARPprovided by HGNC
    Official Full Name
    TCDD inducible poly(ADP-ribose) polymeraseprovided by HGNC
    Primary source
    HGNC:HGNC:23696
    See related
    Ensembl:ENSG00000163659 MIM:612480; AllianceGenome:HGNC:23696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARP7; ARTD14; pART14
    Summary
    This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 28.8), esophagus (RPKM 23.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q25.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (156674590..156706770)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (159449273..159481452)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156392379..156424559)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 1 Neighboring gene uncharacterized LOC124906298 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156174295-156175494 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:156180752-156181363 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156200851-156202050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:156251527-156252026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20728 Neighboring gene signal sequence receptor subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14837 Neighboring gene TIPARP antisense RNA 1 Neighboring gene methyltransferase like 15 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:156468641-156469394 Neighboring gene long intergenic non-protein coding RNA 886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20732 Neighboring gene proliferation-associated 2G4 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TIPARP is involved in the regulation of intraocular pressure. Zhang Y, et al. Commun Biol, 2022 Dec 19. PMID 36536086, Free PMC Article
    2. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Gozgit JM, et al. Cancer Cell, 2021 Sep 13. PMID 34375612
    3. Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. Palavalli Parsons LH, et al. Elife, 2021 Jan 21. PMID 33475085, Free PMC Article
    4. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. de Waard PW, et al. Chem Biol Interact, 2008 Oct 22. PMID 18762178
    5. PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells. Rasmussen M, et al. Cells, 2021 Mar 11. PMID 33799807, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus.
      Title: Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus.
    2. PARP7-mediated ADP-ribosylation of FRA1 promotes cancer cell growth by repressing IRF1- and IRF3-dependent apoptosis.
      Title: PARP7-mediated ADP-ribosylation of FRA1 promotes cancer cell growth by repressing IRF1- and IRF3-dependent apoptosis.
    3. Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells.
      Title: Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells.
    4. TIPARP is involved in the regulation of intraocular pressure.
      Title: TIPARP is involved in the regulation of intraocular pressure.
    5. Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells.
      Title: Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells.
    6. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
      Title: Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
    7. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
      Title: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
    8. PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.
      Title: PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.
    9. PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor alpha Signaling in Human Breast Cancer Cells.
      Title: PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells.
    10. Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
      Title: Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
    EBI GWAS Catalog
    Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
    EBI GWAS Catalog
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40466, DKFZp434J214, DKFZp686N0351, DKFZp686P1838

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+- protein-cysteine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in face morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to 2,3,7,8-tetrachlorodibenzodioxine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase TIPARP
    Names
    ADP-ribosyltransferase diphtheria toxin-like 14
    poly [ADP-ribose] polymerase 7
    NP_001171646.1
    NP_001171647.1
    NP_056323.2
    XP_047303891.1
    XP_047303892.1
    XP_047303893.1
    XP_054202092.1
    XP_054202093.1
    XP_054202094.1
    XP_054202095.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184717.1 → NP_001171646.1  protein mono-ADP-ribosyltransferase TIPARP

      See identical proteins and their annotated locations for NP_001171646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC092927, BC050350, BX537965
      Consensus CDS
      CCDS3177.1
      UniProtKB/Swiss-Prot
      D3DNK6, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7
      UniProtKB/TrEMBL
      A8K5E6
      Related
      ENSP00000420612.1, ENST00000461166.5
      Conserved Domains (3) summary
      cd01439
      Location:529 → 648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:466 → 648
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl02729
      Location:346 → 401
      WWE; WWE domain

    2. NM_001184718.2 → NP_001171647.1  protein mono-ADP-ribosyltransferase TIPARP

      See identical proteins and their annotated locations for NP_001171647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC092927, BC034397, BC050350, BX537965
      Consensus CDS
      CCDS3177.1
      UniProtKB/Swiss-Prot
      D3DNK6, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7
      UniProtKB/TrEMBL
      A8K5E6
      Related
      ENSP00000438345.1, ENST00000542783.5
      Conserved Domains (3) summary
      cd01439
      Location:529 → 648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:466 → 648
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl02729
      Location:346 → 401
      WWE; WWE domain

    3. NM_015508.5 → NP_056323.2  protein mono-ADP-ribosyltransferase TIPARP

      See identical proteins and their annotated locations for NP_056323.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC092927, BC050350, BX537965
      Consensus CDS
      CCDS3177.1
      UniProtKB/Swiss-Prot
      D3DNK6, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7
      UniProtKB/TrEMBL
      A8K5E6
      Related
      ENSP00000295924.7, ENST00000295924.12
      Conserved Domains (3) summary
      cd01439
      Location:529 → 648
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:466 → 648
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl02729
      Location:346 → 401
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      156674590..156706770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447936.1 → XP_047303892.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

    2. XM_047447937.1 → XP_047303893.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

    3. XM_047447935.1 → XP_047303891.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

      UniProtKB/Swiss-Prot
      D3DNK6, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      159449273..159481452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346118.1 → XP_054202093.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

    2. XM_054346117.1 → XP_054202092.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

      UniProtKB/Swiss-Prot
      D3DNK6, Q68CY9, Q7Z3E1, Q86VP4, Q9Y4P7

    3. XM_054346119.1 → XP_054202094.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

    4. XM_054346120.1 → XP_054202095.1  protein mono-ADP-ribosyltransferase TIPARP isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z3E1.1 GenPept UniProtKB/Swiss-Prot:Q7Z3E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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