U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ackr4 atypical chemokine receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 252837, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ackr4provided by MGI
    Official Full Name
    atypical chemokine receptor 4provided by MGI
    Primary source
    MGI:MGI:2181676
    See related
    Ensembl:ENSMUSG00000079355 AllianceGenome:MGI:2181676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPR1; CCBP2; CCR11; Ccrl1; VSHK1; CCX-CKR; Cmkbrl1; CCX-CKR1; A630091E18Rik
    Summary
    Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and sensory organ. Orthologous to human ACKR4 (atypical chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in genital fat pad adult (RPKM 3.0), colon adult (RPKM 2.0) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 F1; 9 56.47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103974881..104003842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104097682..104126643, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Bastow CR, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33875601, Free PMC Article
    2. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. Fujimoto N, et al. PLoS Biol, 2020 Apr. PMID 32251437, Free PMC Article
    3. Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators. Thomson CA, et al. J Immunol, 2018 Jul 1. PMID 29760193, Free PMC Article
    4. Atypical chemokine receptor 4 shapes activated B cell fate. Kara EE, et al. J Exp Med, 2018 Mar 5. PMID 29386231, Free PMC Article
    5. CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. Lucas B, et al. Eur J Immunol, 2015 Feb. PMID 25521433

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
      Title: Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
    2. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
      Title: Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
    3. Expression of ACKR4 demarcates the ""peri-marginal sinus,"" a specialized vascular compartment of the splenic red pulp.
      Title: Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
    4. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
      Title: Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
    5. Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
      Title: Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
    6. ACKR4 restrains antitumor immunity by regulating CCL21.
      Title: ACKR4 restrains antitumor immunity by regulating CCL21.
    7. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
      Title: CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
    8. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
      Title: B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
    9. atypical chemokine receptor 4 (ACKR4), is a identified a decoy receptor that binds and degrades CCR7 ligands CCL19/CCL21, as a regulator of early activated B cell differentiation.
      Title: Atypical chemokine receptor 4 shapes activated B cell fate.
    10. a comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
      Title: A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    atypical chemokine receptor 4
    Names
    C-C CKR-11
    C-C chemokine receptor type 11
    CC chemokine receptor-like 1
    CC-CKR-11
    CCR-11
    CCX CKR
    chemokine (C-C motif) receptor-like 1
    chemokine (C-C) receptor-like 1
    chemokine receptor CCR11

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145700.2 → NP_663746.2  atypical chemokine receptor 4

      See identical proteins and their annotated locations for NP_663746.2

      Status: VALIDATED

      Source sequence(s)
      AC145736, AK030643, AK042430, BB151172, BC140999
      Consensus CDS
      CCDS23459.1
      UniProtKB/Swiss-Prot
      Q8C0M1, Q8QZW9, Q924I3
      UniProtKB/TrEMBL
      B2RU75
      Related
      ENSMUSP00000075507.4, ENSMUST00000076147.6
      Conserved Domains (1) summary
      cd15176
      Location:42 → 314
      7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103974881..104003842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511735.5 → XP_006511798.1  atypical chemokine receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006511798.1

      UniProtKB/Swiss-Prot
      Q8C0M1, Q8QZW9, Q924I3
      UniProtKB/TrEMBL
      B2RU75
      Related
      ENSMUSP00000140792.2, ENSMUST00000188000.2
      Conserved Domains (1) summary
      cd15176
      Location:42 → 314
      7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924I3.1 GenPept UniProtKB/Swiss-Prot:Q924I3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous