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    PAGE2 PAGE family member 2 [ Homo sapiens (human) ]

    Gene ID: 203569, updated on 10-Oct-2023

    Summary

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    Official Symbol
    PAGE2provided by HGNC
    Official Full Name
    PAGE family member 2provided by HGNC
    Primary source
    HGNC:HGNC:31804
    See related
    Ensembl:ENSG00000234068 MIM:300738; AllianceGenome:HGNC:31804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT16.4; GAGEC2; GAGEE2; PAGE-2
    Expression
    Restricted expression toward testis (RPKM 10.7) See more
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    Genomic context

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    Location:
    Xp11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55089018..55092842)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54382141..54385964)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55115451..55119275)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ALAS2 intronic erythroid enhancer Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene ALAS2 intron 1 and 3 erythroid regulatory elements Neighboring gene 5'-aminolevulinate synthase 2 Neighboring gene PAGE family member 2B Neighboring gene HDGFL3 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1184 Neighboring gene component of oligomeric golgi complex 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:55187406-55187906 Neighboring gene VCP nuclear cofactor family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. Yilmaz-Ozcan S, et al. PLoS One, 2014. PMID 25229454, Free PMC Article
    2. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. Brinkmann U, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724777, Free PMC Article
    3. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
    4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition
      Title: Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC62094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P antigen family member 2
    Names
    G antigen family C 2
    G antigen, family E, 2
    P antigen family, member 2 (prostate associated)
    g antigen family E member 2
    prostate-associated gene 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207339.4 → NP_997222.1  P antigen family member 2

      See identical proteins and their annotated locations for NP_997222.1

      Status: VALIDATED

      Source sequence(s)
      AA815378, AL590240, BC054022, BX113994
      Consensus CDS
      CCDS14367.1
      UniProtKB/Swiss-Prot
      Q5JRK7, Q5JRK8, Q7Z2X7
      UniProtKB/TrEMBL
      X6R922
      Related
      ENSP00000364107.4, ENST00000374968.9
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      55089018..55092842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029353.2 → XP_016884842.1  P antigen family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5JRK7, Q5JRK8, Q7Z2X7
      UniProtKB/TrEMBL
      X6R922
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      54382141..54385964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2X7.1 GenPept UniProtKB/Swiss-Prot:Q7Z2X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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