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    Nfyc nuclear transcription factor-Y gamma [ Mus musculus (house mouse) ]

    Gene ID: 18046, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Nfycprovided by MGI
    Official Full Name
    nuclear transcription factor-Y gammaprovided by MGI
    Primary source
    MGI:MGI:107901
    See related
    Ensembl:ENSMUSG00000032897 AllianceGenome:MGI:107901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 46.0), thymus adult (RPKM 39.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.1; 4 56.52 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120614632..120688776, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120757435..120831579, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10253 Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene potassium voltage-gated channel, subfamily Q, member 4 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f Neighboring gene STARR-seq mESC enhancer starr_11254 Neighboring gene STARR-positive B cell enhancer ABC_E3507 Neighboring gene STARR-seq mESC enhancer starr_11255 Neighboring gene STARR-seq mESC enhancer starr_11256 Neighboring gene STARR-positive B cell enhancer mm9_chr4:120523542-120523843 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene STARR-positive B cell enhancer ABC_E4657 Neighboring gene STARR-positive B cell enhancer ABC_E4658 Neighboring gene 60S ribosomal protein L26-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor. Orita T, et al. J Biol Chem, 1997 Sep 12. PMID 9287329
    2. Transforming growth factor β1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. Castro NE, et al. J Biol Chem, 2014 Oct 17. PMID 25204661, Free PMC Article
    3. Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors. Oldfield AJ, et al. Mol Cell, 2014 Sep 4. PMID 25132174, Free PMC Article
    4. Nuclear factor Y (NF-Y) and cellular senescence. Matuoka K, et al. Exp Cell Res, 1999 Dec 15. PMID 10585259
    5. Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. Nakshatri H, et al. J Biol Chem, 1996 Nov 15. PMID 8910521

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor
      Title: p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear transcription factor Y subunit gamma
    Names
    CAAT box DNA-binding protein subunit C
    nuclear transcription factor Y subunit C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048168.3 → NP_001041633.1  nuclear transcription factor Y subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_001041633.1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      Consensus CDS
      CCDS18594.1
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Related
      ENSMUSP00000112610.2, ENSMUST00000118902.8
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    2. NM_001277095.2 → NP_001264024.1  nuclear transcription factor Y subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001264024.1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      UniProtKB/TrEMBL
      Q3U114
      Conserved Domains (1) summary
      cl23735
      Location:42 → 60
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    3. NM_001357192.2 → NP_001344121.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      Consensus CDS
      CCDS18594.1
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Related
      ENSMUSP00000112810.2, ENSMUST00000120779.8
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    4. NM_001357193.2 → NP_001344122.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      Consensus CDS
      CCDS18594.1
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    5. NM_001357194.2 → NP_001344123.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      Consensus CDS
      CCDS18594.1
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    6. NM_001421278.1 → NP_001408207.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21

    7. NM_001421279.1 → NP_001408208.1  nuclear transcription factor Y subunit gamma isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    8. NM_001421282.1 → NP_001408211.1  nuclear transcription factor Y subunit gamma isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    9. NM_001421285.1 → NP_001408214.1  nuclear transcription factor Y subunit gamma isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    10. NM_001421286.1 → NP_001408215.1  nuclear transcription factor Y subunit gamma isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    11. NM_001421287.1 → NP_001408216.1  nuclear transcription factor Y subunit gamma isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    12. NM_001421288.1 → NP_001408217.1  nuclear transcription factor Y subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    13. NM_001421289.1 → NP_001408218.1  nuclear transcription factor Y subunit gamma isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    14. NM_001421290.1 → NP_001408219.1  nuclear transcription factor Y subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    15. NM_001421291.1 → NP_001408220.1  nuclear transcription factor Y subunit gamma isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    16. NM_001421292.1 → NP_001408221.1  nuclear transcription factor Y subunit gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    17. NM_001421293.1 → NP_001408222.1  nuclear transcription factor Y subunit gamma isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    18. NM_001421294.1 → NP_001408223.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21

    19. NM_001421295.1 → NP_001408224.1  nuclear transcription factor Y subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21

    20. NM_001421296.1 → NP_001408225.1  nuclear transcription factor Y subunit gamma isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    21. NM_008692.5 → NP_032718.2  nuclear transcription factor Y subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_032718.2

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924
      Consensus CDS
      CCDS18594.1
      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Related
      ENSMUSP00000047441.6, ENSMUST00000043429.12
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    RNA

    1. NR_185291.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    2. NR_185292.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL606924

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120614632..120688776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253307.1 → XP_030109167.1  nuclear transcription factor Y subunit gamma isoform X4

      Conserved Domains (1) summary
      COG5208
      Location:23 → 61
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    2. XM_036163814.1 → XP_036019707.1  nuclear transcription factor Y subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      O35088, P70353, Q6GU21
      UniProtKB/TrEMBL
      Q7TPS7
      Related
      ENSMUSP00000095516.6, ENSMUST00000097906.12
      Conserved Domains (1) summary
      COG5208
      Location:17 → 123
      HAP5; CCAAT-binding factor, subunit C [Transcription]

    RNA

    1. XR_004941831.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70353.2 GenPept UniProtKB/Swiss-Prot:P70353

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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