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    Gpr19 G protein-coupled receptor 19 [ Mus musculus (house mouse) ]

    Gene ID: 14760, updated on 12-May-2024

    Summary

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    Official Symbol
    Gpr19provided by MGI
    Official Full Name
    G protein-coupled receptor 19provided by MGI
    Primary source
    MGI:MGI:892973
    See related
    Ensembl:ENSMUSG00000032641 AllianceGenome:MGI:892973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Located in cilium. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and skeleton. Orthologous to human GPR19 (G protein-coupled receptor 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.5), whole brain E14.5 (RPKM 5.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G1; 6 65.77 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134846055..134875157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134869092..134898194, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055D16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3688 Neighboring gene predicted gene, 53343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134779903-134780086 Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene CRISPRi-validated cis-regulatory element for Cdkn1b and Gpr19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134848417-134848526 Neighboring gene predicted gene, 53344 Neighboring gene STARR-positive B cell enhancer ABC_E285 Neighboring gene cyclin dependent kinase inhibitor 1B Neighboring gene lncRNA downstream of Cdkn1b Neighboring gene STARR-positive B cell enhancer mm9_chr6:134897243-134897544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction. Mushala BAS, et al. Sci Rep, 2023 Apr 15. PMID 37061564, Free PMC Article
    2. Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock. Yamaguchi Y, et al. Sci Rep, 2021 Nov 17. PMID 34789778, Free PMC Article
    3. The orphan G-protein-coupled receptor GPR19 is expressed predominantly in neuronal cells during mouse embryogenesis. Hoffmeister-Ullerich SA, et al. Cell Tissue Res, 2004 Nov. PMID 15452705
    4. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Doi M, et al. Nat Commun, 2016 Feb 17. PMID 26882873, Free PMC Article
    5. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. Badgandi HB, et al. J Cell Biol, 2017 Mar 6. PMID 28154160, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
      Title: Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
    2. G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
      Title: G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
    3. Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
      Title: Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167694.2 → NP_001161166.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161166.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (a). Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK140770, BY712856, DV660907
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121, Q810I4, Q8VDJ9
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Related
      ENSMUSP00000047630.8, ENSMUST00000046255.14
      Conserved Domains (1) summary
      cd15008
      Location:67 → 341
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001167695.2 → NP_001161167.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK140770
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001167696.2 → NP_001161168.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, DV651999
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Related
      ENSMUSP00000127876.2, ENSMUST00000165392.8
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001167697.2 → NP_001161169.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK132917, BB853775, BQ558507
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121, Q810I4, Q8VDJ9
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:67 → 341
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001167699.2 → NP_001161171.1  probable G-protein coupled receptor 19 isoform a

      See identical proteins and their annotated locations for NP_001161171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.
      Source sequence(s)
      AC122193, AK132917, BB853775, BQ558507, BY275399, BY291247
      Consensus CDS
      CCDS51937.1
      UniProtKB/Swiss-Prot
      Q61121, Q810I4, Q8VDJ9
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:67 → 341
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_001167700.2 → NP_001161172.1  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_001161172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, BY712856
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Related
      ENSMUSP00000107563.2, ENSMUST00000111932.8
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. NM_001362048.1 → NP_001348977.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 8-12, encodes isoform b.
      Source sequence(s)
      AC122193
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Related
      ENSMUSP00000112214.3, ENSMUST00000116515.9
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    8. NM_001362049.1 → NP_001348978.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 4, 5, 8, and 10-12, encodes isoform b.
      Source sequence(s)
      AC122193
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. NM_001362050.1 → NP_001348979.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 4, 5, 8, 9, 11, and 12, encodes the same isoform (b).
      Source sequence(s)
      AC122193
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    10. NM_001362051.1 → NP_001348980.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 4, 5, 8-10, and 12, encodes isoform b.
      Source sequence(s)
      AC122193
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    11. NM_001362052.1 → NP_001348981.1  probable G-protein coupled receptor 19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, 4, 5, and 8-11, encodes isoform b.
      Source sequence(s)
      AC122193
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    12. NM_008157.3 → NP_032183.2  probable G-protein coupled receptor 19 isoform b

      See identical proteins and their annotated locations for NP_032183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.
      Source sequence(s)
      AC122193, AK132917, BB853775, BY275399
      Consensus CDS
      CCDS20641.1
      UniProtKB/TrEMBL
      A0A1L1SSP1
      Conserved Domains (1) summary
      cd15008
      Location:61 → 335
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_155270.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122193, BY712856
      Related
      ENSMUST00000152140.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134846055..134875157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001167693.1: Suppressed sequence

      Description
      NM_001167693.1: This RefSeq was permanently suppressed because a small upstream ORF with a strong Kozak signal overlaps the expected translation start site, making it unlikely that this transcript is translated.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61121.2 GenPept UniProtKB/Swiss-Prot:Q61121

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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