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    0610010K14Rik RIKEN cDNA 0610010K14 gene [ Mus musculus (house mouse) ]

    Gene ID: 104457, updated on 30-Apr-2024

    Summary

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    Official Symbol
    0610010K14Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 0610010K14 geneprovided by MGI
    Primary source
    MGI:MGI:1915609
    See related
    Ensembl:ENSMUSG00000020831 AllianceGenome:MGI:1915609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bap18; 1110020A23Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex and NURF complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; leg; and nervous system. Orthologous to human C17orf49 (chromosome 17 open reading frame 49). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 52.3), CNS E14 (RPKM 43.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70126030..70128808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70235204..70237923, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 497b Neighboring gene microRNA 195a Neighboring gene microRNA 497 Neighboring gene STARR-positive B cell enhancer ABC_E1832 Neighboring gene STARR-positive B cell enhancer ABC_E2998 Neighboring gene ribonuclease, RNase K Neighboring gene predicted gene, 40191 Neighboring gene arachidonate 12-lipoxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    2. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
    3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NURF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chromatin complexes subunit BAP18
    Names
    BPTF-associated protein of 18 kDa
    MLL1/MLL complex subunit C17orf49 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177601.1 → NP_001171072.1  chromatin complexes subunit BAP18 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AA189586, AK003842, CK791552, EL959640
      Consensus CDS
      CCDS48834.1
      UniProtKB/TrEMBL
      D3Z687
      Related
      ENSMUSP00000104216.4, ENSMUST00000108576.10
      Conserved Domains (2) summary
      smart00717
      Location:41 → 77
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:41 → 77
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. NM_001177603.1 → NP_001171074.1  chromatin complexes subunit BAP18 isoform 3

      See identical proteins and their annotated locations for NP_001171074.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AA189586, AW557771, CB192659
      Consensus CDS
      CCDS48833.1
      UniProtKB/TrEMBL
      F6XN97
      Related
      ENSMUSP00000021181.7, ENSMUST00000021181.13
      Conserved Domains (2) summary
      smart00717
      Location:41 → 77
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:41 → 77
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. NM_001177606.1 → NP_001171077.1  chromatin complexes subunit BAP18 isoform 5

      See identical proteins and their annotated locations for NP_001171077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate, in-frame exons, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AA189586, AK003842, AK169173
      Consensus CDS
      CCDS48832.1
      UniProtKB/TrEMBL
      A2CF80
      Related
      ENSMUSP00000104220.2, ENSMUST00000108579.8

    4. NM_001177607.1 → NP_001171078.1  chromatin complexes subunit BAP18 isoform 6

      See identical proteins and their annotated locations for NP_001171078.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate, in-frame exons and uses a different splice site in the 3' UTR, compared to variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminue when it is compared to isoform 1.
      Source sequence(s)
      AA189586, AK003842, BE861439
      Consensus CDS
      CCDS48831.1
      UniProtKB/TrEMBL
      A2CF80, A2CF83
      Related
      ENSMUSP00000104215.3, ENSMUST00000108575.9

    5. NM_026757.2 → NP_081033.1  chromatin complexes subunit BAP18 isoform 4

      See identical proteins and their annotated locations for NP_081033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate, in-frame exon in the 5' coding region and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus when compared to isoform 1.
      Source sequence(s)
      AA189586, AK003842
      Consensus CDS
      CCDS24940.1
      UniProtKB/Swiss-Prot
      Q9DCT6
      Related
      ENSMUSP00000099629.4, ENSMUST00000102569.10

    6. NM_145758.1 → NP_665701.1  chromatin complexes subunit BAP18 isoform 2

      See identical proteins and their annotated locations for NP_665701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA189586, AK002491, AK003842
      Consensus CDS
      CCDS48835.1
      UniProtKB/Swiss-Prot
      Q3TFE6, Q7TMP3, Q9D183, Q9DCT6
      UniProtKB/TrEMBL
      F6XN97
      Related
      ENSMUSP00000104219.3, ENSMUST00000108578.9
      Conserved Domains (2) summary
      smart00717
      Location:41 → 77
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:41 → 77
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70126030..70128808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245456.2 → XP_030101316.1  chromatin complexes subunit BAP18 isoform X2

      UniProtKB/TrEMBL
      A2CF80, A2CF83

    2. XM_017314213.3 → XP_017169702.1  chromatin complexes subunit BAP18 isoform X1

    RNA

    1. XR_003949208.2 RNA Sequence

    2. XR_003949207.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCT6.1 GenPept UniProtKB/Swiss-Prot:Q9DCT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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