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    SYT15B synaptotagmin 15B [ Homo sapiens (human) ]

    Gene ID: 102724488, updated on 10-Mar-2024

    Summary

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    Official Symbol
    SYT15Bprovided by HGNC
    Official Full Name
    synaptotagmin 15Bprovided by HGNC
    Primary source
    HGNC:HGNC:51487
    See related
    Ensembl:ENSG00000277758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in lung (RPKM 7.5), lymph node (RPKM 1.7) and 17 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    10q11.22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47744717..47763592, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48636126..48655007, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene annexin A8 Neighboring gene uncharacterized LOC102724603 Neighboring gene shieldin complex subunit 2 pseudogene 3 Neighboring gene uncharacterized LOC124902422 Neighboring gene uncharacterized LOC102724593 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47089387-47089886 Neighboring gene neuropeptide Y receptor Y4-2 Neighboring gene uncharacterized LOC124902423

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    synaptotagmin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370182.1 → NP_001357111.1  synaptotagmin-15 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      FO681492
      Consensus CDS
      CCDS91240.1
      UniProtKB/Swiss-Prot
      X6R8R1
      Related
      ENSP00000485217.1, ENST00000623662.4
      Conserved Domains (2) summary
      cd08390
      Location:202 → 322
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:332 → 469
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    2. NM_001370183.1 → NP_001357112.1  synaptotagmin-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      FO681492
      UniProtKB/TrEMBL
      A8K2C1
      Conserved Domains (2) summary
      cd08390
      Location:156 → 276
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:286 → 423
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    3. NM_001370184.1 → NP_001357113.1  synaptotagmin-15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      FO681492
      Consensus CDS
      CCDS91239.1
      UniProtKB/Swiss-Prot
      A5D6W8, Q5VY53, Q5VY55, Q7Z439, Q7Z440, Q9BQS2
      UniProtKB/TrEMBL
      A8K2C1
      Related
      ENSP00000478933.3, ENST00000615923.4
      Conserved Domains (2) summary
      cd08390
      Location:149 → 269
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:279 → 416
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    4. NM_001370185.1 → NP_001357114.1  synaptotagmin-15 isoform 4

      Status: VALIDATED

      Source sequence(s)
      FO681492
      UniProtKB/TrEMBL
      A8K2C1
      Conserved Domains (2) summary
      cd08390
      Location:103 → 223
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:233 → 370
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    5. NM_001370186.1 → NP_001357115.1  synaptotagmin-15 isoform 5

      Status: VALIDATED

      Source sequence(s)
      DB474425, FO681492
      UniProtKB/TrEMBL
      B4DEH7
      Conserved Domains (2) summary
      cd08390
      Location:33 → 153
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08409
      Location:163 → 300
      C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      47744717..47763592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540438.4 → XP_011538740.1  synaptotagmin-15 isoform X1

      See identical proteins and their annotated locations for XP_011538740.1

      Conserved Domains (2) summary
      cd08390
      Location:209 → 329
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:339 → 438
      C2; C2 domain

    2. XM_011540436.4 → XP_011538738.1  synaptotagmin-15 isoform X1

      See identical proteins and their annotated locations for XP_011538738.1

      Conserved Domains (2) summary
      cd08390
      Location:209 → 329
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:339 → 438
      C2; C2 domain

    3. XM_011540437.3 → XP_011538739.1  synaptotagmin-15 isoform X1

      See identical proteins and their annotated locations for XP_011538739.1

      Conserved Domains (2) summary
      cd08390
      Location:209 → 329
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:339 → 438
      C2; C2 domain

    4. XM_047424437.1 → XP_047280393.1  synaptotagmin-15 isoform X2

    5. XM_011540435.4 → XP_011538737.1  synaptotagmin-15 isoform X1

      See identical proteins and their annotated locations for XP_011538737.1

      Conserved Domains (2) summary
      cd08390
      Location:209 → 329
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cl14603
      Location:339 → 438
      C2; C2 domain

    6. XM_047424435.1 → XP_047280391.1  synaptotagmin-15 isoform X1

    RNA

    1. XR_001747444.3 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160001.1 Reference GRCh38.p14 PATCHES

      Range
      5568..24443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332441.1 → XP_054188416.1  synaptotagmin-15 isoform X1

    2. XM_054332439.1 → XP_054188414.1  synaptotagmin-15 isoform X1

    3. XM_054332443.1 → XP_054188418.1  synaptotagmin-15 isoform X1

    4. XM_054332444.1 → XP_054188419.1  synaptotagmin-15 isoform X2

    5. XM_054332442.1 → XP_054188417.1  synaptotagmin-15 isoform X1

    6. XM_054332440.1 → XP_054188415.1  synaptotagmin-15 isoform X1

    RNA

    1. XR_008485776.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      48636126..48655007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364475.1 → XP_054220450.1  synaptotagmin-15 isoform X1

    2. XM_054364480.1 → XP_054220455.1  synaptotagmin-15 isoform X2

    3. XM_054364474.1 → XP_054220449.1  synaptotagmin-15 isoform X1

    4. XM_054364478.1 → XP_054220453.1  synaptotagmin-15 isoform X1

    5. XM_054364479.1 → XP_054220454.1  synaptotagmin-15 isoform X2

    6. XM_054364477.1 → XP_054220452.1  synaptotagmin-15 isoform X1

    7. XM_054364476.1 → XP_054220451.1  synaptotagmin-15 isoform X1

    RNA

    1. XR_008488153.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
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    Research Materials