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    Dcun1d2 defective in cullin neddylation 1 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 102323, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dcun1d2provided by MGI
    Official Full Name
    defective in cullin neddylation 1 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2142792
    See related
    Ensembl:ENSMUSG00000038506 AllianceGenome:MGI:2142792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCNL2; mFLJ10704
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; positive regulation of ubiquitin-protein transferase activity; and protein neddylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 17.4), cerebellum adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13305963..13337833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13255963..13288126, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene STARR-seq mESC enhancer starr_20764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213467-13213836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213972-13214173 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene transcription factor Dp 1 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz T, et al. Nature, 2005 Jun 30. PMID 15988528
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 2
    Names
    DCN1, defective in cullin neddylation 1, domain containing 2
    DCUN1 domain-containing protein 2
    defective in cullin neddylation protein 1-like protein 2
    squamous cell carcinoma-related oncogene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024504.3 → NP_001019675.2  DCN1-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_001019675.2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS40228.1
      UniProtKB/Swiss-Prot
      Q3U1U0, Q7TMX3, Q8BZJ7
      Related
      ENSMUSP00000047208.8, ENSMUST00000045366.10
      Conserved Domains (2) summary
      pfam03556
      Location:137 → 247
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 48
      UBA_like_SF; UBA domain-like superfamily

    2. NM_001042649.2 → NP_001036114.1  DCN1-like protein 2 isoform c

      See identical proteins and their annotated locations for NP_001036114.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS40230.1
      UniProtKB/TrEMBL
      G5E8Q5, Q3TSY8
      Related
      ENSMUSP00000106462.2, ENSMUST00000110838.8
      Conserved Domains (2) summary
      pfam03556
      Location:137 → 173
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 48
      UBA_like_SF; UBA domain-like superfamily

    3. NM_001042650.2 → NP_001036115.1  DCN1-like protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS40227.1
      UniProtKB/TrEMBL
      Q3TSY8
      Related
      ENSMUSP00000106464.2, ENSMUST00000110840.8
      Conserved Domains (2) summary
      pfam03556
      Location:137 → 187
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 48
      UBA_like_SF; UBA domain-like superfamily

    4. NM_001042651.2 → NP_001036116.1  DCN1-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001036116.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS40229.1
      UniProtKB/TrEMBL
      G5E8Q6, Q3TSY8
      Related
      ENSMUSP00000106463.4, ENSMUST00000110839.10
      Conserved Domains (2) summary
      pfam03556
      Location:137 → 203
      Cullin_binding; Cullin binding
      cl21463
      Location:2 → 48
      UBA_like_SF; UBA domain-like superfamily

    5. NM_001426633.1 → NP_001413562.1  DCN1-like protein 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC130818

    6. NM_001426634.1 → NP_001413563.1  DCN1-like protein 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC130818

    7. NM_001426635.1 → NP_001413564.1  DCN1-like protein 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC130818

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13305963..13337833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZJ7.3 GenPept UniProtKB/Swiss-Prot:Q8BZJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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