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    EPIST esophagus epithelial intergenic associated transcript [ Homo sapiens (human) ]

    Gene ID: 101927953, updated on 10-Oct-2023

    Summary

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    Official Symbol
    EPISTprovided by HGNC
    Official Full Name
    esophagus epithelial intergenic associated transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:49679
    See related
    Ensembl:ENSG00000249082 AllianceGenome:HGNC:49679
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5orf66-AS1
    Expression
    Biased expression in salivary gland (RPKM 1.5), esophagus (RPKM 0.8) and 7 other tissues See more
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    Genomic context

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    Location:
    5q31.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135038831..135040047, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (135565846..135567062, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134374521..134375737, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:134312555-134313067 Neighboring gene cation channel sperm associated 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:134325851-134326415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:134360625-134361824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134362037-134362626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134362736-134363421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134364793-134365477 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:134367424-134367631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134368802-134369434 Neighboring gene PITX1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134384389-134384989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134386169-134386753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23167 Neighboring gene paired like homeodomain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134401324-134402015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134403398-134404087 Neighboring gene uncharacterized LOC124901072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134470142-134471024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134471025-134471907 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:134509397-134509555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134549501-134550001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134563187-134563687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134565392-134565953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134574510-134575316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:134582317-134583516 Neighboring gene long intergenic non-protein coding RNA 2900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aberrant methylation-mediated silencing of lncRNA CTC-276P9.1 is associated with malignant progression of esophageal squamous cell carcinoma. Guo W, et al. Clin Exp Metastasis, 2018 Feb. PMID 29524086
    2. Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor. Wei G, et al. Oncotarget, 2015 Jul 10. PMID 26158411, Free PMC Article
    3. Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis. Rui X, et al. Cell Death Dis, 2018 Dec 5. PMID 30518760, Free PMC Article
    4. Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness. Yu G, et al. Oncol Rep, 2017 Aug. PMID 28656268, Free PMC Article
    5. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA C5orf66-AS1, as a competitive endogenous RNA, regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637.
      Title: Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis.
    2. Low C5orf66-AS1 expression is associated with pituitary null cell adenomas.
      Title: Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
    3. our analysis of the Esophageal Squamous Cell Carcinoma transcriptome identified the potential tumor suppressing lncRNA Epist
      Title: Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • C5orf66 antisense RNA 1
    • esophagus epithelial intergenic specific transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_105049.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC008406, BE785577, BY798674
      Related
      ENST00000507035.2

    2. NR_105050.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC008406

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      135038831..135040047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      135565846..135567062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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