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    PTCSC1 papillary thyroid carcinoma susceptibility candidate 1 [ Homo sapiens (human) ]

    Gene ID: 100302522, updated on 10-Oct-2023

    Summary

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    Official Symbol
    PTCSC1provided by HGNC
    Official Full Name
    papillary thyroid carcinoma susceptibility candidate 1provided by HGNC
    Primary source
    HGNC:HGNC:37127
    See related
    Ensembl:ENSG00000287736 MIM:617440; AllianceGenome:HGNC:37127
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTCSC; NCRNA00197
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    Genomic context

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    Location:
    8q24.22
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (133054959..133057767)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (134178385..134181151)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134067204..134070012)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyroglobulin Neighboring gene uncharacterized LOC105375768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:134061257-134062456 Neighboring gene microRNA 7848 Neighboring gene Src like adaptor Neighboring gene uncharacterized LOC105375769 Neighboring gene NANOG hESC enhancer GRCh37_chr8:134157066-134157567 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:134194436-134195635 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134204154-134204401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134208271-134208770 Neighboring gene uncharacterized LOC102723635 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:134224019-134225218 Neighboring gene cellular communication network factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The long non-coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. Ye B, et al. Exp Ther Med, 2017 Oct. PMID 29042961, Free PMC Article
    2. LncRNA AK023948 is a positive regulator of AKT. Koirala P, et al. Nat Commun, 2017 Feb 8. PMID 28176758, Free PMC Article
    3. A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24. He H, et al. Cancer Res, 2009 Jan 15. PMID 19147577, Free PMC Article
    4. Long noncoding RNA PTCSC1 drives esophageal squamous cell carcinoma progression through activating Akt signaling. Liu T, et al. Exp Mol Pathol, 2020 Dec. PMID 32971114
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA PTCSC1 drives esophageal squamous cell carcinoma progression through activating Akt signaling.
      Title: Long noncoding RNA PTCSC1 drives esophageal squamous cell carcinoma progression through activating Akt signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Genotypes

    General gene information

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    Other Names

    • papillary thyroid carcinoma susceptibility candidate (non-protein coding)
    • papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_146773.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305872
      Related
      ENST00000664551.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      133054959..133057767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      134178385..134181151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases