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    TMEM221 transmembrane protein 221 [ Homo sapiens (human) ]

    Gene ID: 100130519, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TMEM221provided by HGNC
    Official Full Name
    transmembrane protein 221provided by HGNC
    Primary source
    HGNC:HGNC:21943
    See related
    Ensembl:ENSG00000188051 AllianceGenome:HGNC:21943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Jiraiya
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary (RPKM 1.6), adrenal (RPKM 1.1) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19p13.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17435509..17448668, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17570277..17583426, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17546318..17559477, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17518151-17518677 Neighboring gene multivesicular body subunit 12A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:17525723-17526510 Neighboring gene BST2 interferon stimulated positive regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10344 Neighboring gene high mobility group box 3 pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17534662-17535187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17571641-17572141 Neighboring gene nucleoredoxin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17581949-17582450 Neighboring gene Sharpr-MPRA regulatory region 2801 Neighboring gene solute carrier family 27 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17593839-17594340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14275 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17599959-17600122 Neighboring gene PGLS divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17609403-17609947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17610300-17611168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17611169-17612037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning. Aramaki T, et al. Dev Cell, 2010 Oct 19. PMID 20951346
    2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877
    3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 221
    Names
    Putative transmembrane protein ENSP00000342162

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190844.2 → NP_001177773.1  transmembrane protein 221

      See identical proteins and their annotated locations for NP_001177773.1

      Status: VALIDATED

      Source sequence(s)
      AC010319, BY797043
      Consensus CDS
      CCDS54230.1
      UniProtKB/Swiss-Prot
      A6NGB7
      Related
      ENSP00000342162.5, ENST00000341130.6
      Conserved Domains (1) summary
      pfam15038
      Location:32 → 186
      Jiraiya; Jiraiya

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      17435509..17448668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527603.3 → XP_011525905.1  transmembrane protein 221 isoform X1

      See identical proteins and their annotated locations for XP_011525905.1

      Conserved Domains (1) summary
      pfam15038
      Location:32 → 186
      Jiraiya; Jiraiya

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17570277..17583426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319457.1 → XP_054175432.1  transmembrane protein 221 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NGB7.3 GenPept UniProtKB/Swiss-Prot:A6NGB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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