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    FBP26 fructose-2,6-bisphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853286, updated on 17-May-2024

    Summary

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    Gene symbol
    FBP26
    Gene description
    fructose-2,6-bisphosphatase
    Primary source
    FungiDB:YJL155C
    Locus tag
    YJL155C
    See related
    SGD:S000003691; AllianceGenome:SGD:S000003691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in glucose metabolic process. Located in cytoplasm. Orthologous to several human genes including PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) and PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FBP26 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (129285..130643, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 Neighboring gene Ssy5p Neighboring gene retromer subunit VPS35 Neighboring gene inositol-3-phosphate synthase INO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-directed mutagenesis of Lys-174, Asp-179 and Asp-191 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Bertrand L, et al. Biochem J, 1997 Feb 1. PMID 9032446, Free PMC Article
    2. Modelling the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase on adenylate kinase. Bertrand L, et al. Biochem J, 1997 Feb 1. PMID 9032445, Free PMC Article
    3. The yeast FBP26 gene codes for a fructose-2,6-bisphosphatase. Paravicini G, et al. Biochemistry, 1992 Aug 11. PMID 1322693
    4. Genetic manipulation of 6-phosphofructo-1-kinase and fructose 2,6-bisphosphate levels affects the extent to which benzoic acid inhibits the growth of Saccharomyces cerevisiae. Pearce AK, et al. Microbiology (Reading), 2001 Feb. PMID 11158357
    5. Dynamic structures of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in a reconstituted enzyme system. Schellenberger W, et al. Biomed Biochim Acta, 1985. PMID 2994640

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fructose-2,6-bisphosphatase
    NP_012380.1
    • Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      129285..130643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181588.1 → NP_012380.1  TPA: fructose-2,6-bisphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW32, P32604
      UniProtKB/TrEMBL
      A0A8H4FAN0, B3LPW6, B5VL30, C8ZB65, N1P1F9
      Conserved Domains (2) summary
      pfam00300
      Location:227 → 411
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:1 → 224
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32604.2

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