Pygo1 pygopus 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pygo1provided by MGI
Official Full Name: pygopus 1provided by MGI
Primary source: MGI:MGI:1919385
See related: Ensembl:ENSMUSG00000034910 AllianceGenome:MGI:1919385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2600014C22Rik
Summary: Predicted to enable methylated histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; protein localization to nucleus; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; heart; male reproductive system; pancreas; and urinary system. Orthologous to human PYGO1 (pygopus family PHD finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 7.4), whole brain E14.5 (RPKM 6.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 40.08 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (72832927..72859868)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (72925645..72952586)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pygo1 regulates pathological cardiac hypertrophy via a beta-catenin-dependent mechanism.
Title: Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.
Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
Title: The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity
Title: Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
These results suggest that the Pygopus1 plant homeodomain (PHD) dimerization is functionally important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway.
Title: Crystal structure analysis of the PHD domain of the transcription co-activator Pygopus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490776

Pygo1 (e-PCR), detects polymorphism
- UniSTS:545978

RH138058 (e-PCR)
- UniSTS:220145

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anatomical structure development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatid development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatid nucleus differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid nucleus differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pygopus homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.