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    Katnal2 katanin p60 subunit A-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 71206, updated on 12-May-2024

    Summary

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    Official Symbol
    Katnal2provided by MGI
    Official Full Name
    katanin p60 subunit A-like 2provided by MGI
    Primary source
    MGI:MGI:1924234
    See related
    Ensembl:ENSMUSG00000025420 AllianceGenome:MGI:1924234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110023G01Rik; 4933439B08Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and microtubule-severing ATPase activity. Predicted to be located in cytoplasm; microtubule; and spindle pole. Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 8.9), CNS E11.5 (RPKM 2.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Katnal2 in Genome Data Viewer
    Location:
    18 E3; 18 52.02 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77063725..77135007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (76976029..77047311, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45103 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene predicted gene, 53183 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_45107 Neighboring gene STARR-positive B cell enhancer mm9_chr18:77285922-77286223 Neighboring gene RIKEN cDNA 4930520E11 gene Neighboring gene protein inhibitor of activated STAT 2 Neighboring gene STARR-seq mESC enhancer starr_45110 Neighboring gene STARR-seq mESC enhancer starr_45112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse. Dunleavy JEM, et al. PLoS Genet, 2017 Nov. PMID 29136647, Free PMC Article
    2. Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia. Wei X, et al. Clin Genet, 2021 Oct. PMID 34096614
    3. A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells. Ververis A, et al. Cell Mol Life Sci, 2016 Jan. PMID 26153462, Free PMC Article
    4. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia.
      Title: Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia.
    2. Authors present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein KATNB1 or act autonomously. Data indicate KATNAL2 may regulate delta- and epsilon-tubulin rather than classical alpha-beta-tubulin microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised.
      Title: Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse.
    3. KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2.
      Title: A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    katanin p60 ATPase-containing subunit A-like 2
    Names
    p60 katanin-like 2
    NP_001355584.1
    NP_001355585.1
    NP_001355586.1
    NP_081997.1
    XP_036017170.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368655.1 → NP_001355584.1  katanin p60 ATPase-containing subunit A-like 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132608
      Consensus CDS
      CCDS89281.1
      UniProtKB/Swiss-Prot
      Q6NSQ2, Q9D3R6
      UniProtKB/TrEMBL
      A0A0E4HEY7
      Related
      ENSMUSP00000122079.2, ENSMUST00000126153.8
      Conserved Domains (2) summary
      smart00667
      Location:25 → 55
      LisH; Lissencephaly type-1-like homology motif
      COG0464
      Location:239 → 523
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    2. NM_001368656.1 → NP_001355585.1  katanin p60 ATPase-containing subunit A-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132608
      UniProtKB/TrEMBL
      A0A0E4D014
      Related
      ENSMUSP00000117495.2, ENSMUST00000137498.8
      Conserved Domains (2) summary
      smart00667
      Location:25 → 55
      LisH; Lissencephaly type-1-like homology motif
      COG0464
      Location:237 → 521
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    3. NM_001368657.1 → NP_001355586.1  katanin p60 ATPase-containing subunit A-like 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132608
      UniProtKB/TrEMBL
      A0A0E4HEY7
      Conserved Domains (2) summary
      smart00667
      Location:6 → 36
      LisH; Lissencephaly type-1-like homology motif
      COG0464
      Location:220 → 504
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    4. NM_027721.2 → NP_081997.1  katanin p60 ATPase-containing subunit A-like 2 isoform 4

      See identical proteins and their annotated locations for NP_081997.1

      Status: PROVISIONAL

      Source sequence(s)
      AK017114
      Consensus CDS
      CCDS37865.1
      UniProtKB/TrEMBL
      D6RGM7
      Related
      ENSMUSP00000026486.7, ENSMUST00000026486.13
      Conserved Domains (3) summary
      smart00667
      Location:25 → 55
      LisH; Lissencephaly type-1-like homology motif
      COG0464
      Location:239 → 408
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:291 → 406
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77063725..77135007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161277.1 → XP_036017170.1  katanin p60 ATPase-containing subunit A-like 2 isoform X1

      UniProtKB/TrEMBL
      D3Z0U5
      Related
      ENSMUSP00000118511.2, ENSMUST00000137354.8
      Conserved Domains (2) summary
      pfam17862
      Location:228 → 266
      AAA_lid_3; AAA+ lid domain
      cd19509
      Location:28 → 192
      RecA-like_VPS4-like; ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains

    RNA

    1. XR_001782393.2 RNA Sequence

      Related
      ENSMUST00000122984.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3R6.2 GenPept UniProtKB/Swiss-Prot:Q9D3R6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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