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    CCNI2 cyclin I family member 2 [ Homo sapiens (human) ]

    Gene ID: 645121, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CCNI2provided by HGNC
    Official Full Name
    cyclin I family member 2provided by HGNC
    Primary source
    HGNC:HGNC:33869
    See related
    Ensembl:ENSG00000205089 MIM:620419; AllianceGenome:HGNC:33869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 13.3), adrenal (RPKM 2.6) and 18 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CCNI2 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132747426..132756065)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133267163..133275992)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132083118..132090095)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene kinesin family member 3A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23096 Neighboring gene septin 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16337 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150138-132150638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150639-132151139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16341 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16343 Neighboring gene shroom family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CCNI2 plays a promoting role in the progression of colorectal cancer. Lai DM, et al. Cancer Med, 2021 Mar. PMID 33620152, Free PMC Article
    2. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Taneera J, et al. Mol Cell Endocrinol, 2013 Aug 15. PMID 23707792
    3. Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation. Liu C, et al. Sci Rep, 2017 Jan 23. PMID 28112194, Free PMC Article
    4. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article
    5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16793

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-I2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039780.4 → NP_001034869.1  cyclin-I2 isoform 2

      See identical proteins and their annotated locations for NP_001034869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC004775, AK131553, AW131382
      Consensus CDS
      CCDS34236.1
      UniProtKB/Swiss-Prot
      B2RNE2, B7ZMB7, B7ZMB8, Q6ZMN8
      Related
      ENSP00000368005.1, ENST00000378731.6
      Conserved Domains (2) summary
      pfam00134
      Location:156 → 247
      Cyclin_N; Cyclin, N-terminal domain
      cl26386
      Location:3 → 111
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. NM_001287252.2 → NP_001274181.1  cyclin-I2 isoform 1

      See identical proteins and their annotated locations for NP_001274181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004775, AK131553, AW131382, BC144417
      Consensus CDS
      CCDS75297.1
      UniProtKB/Swiss-Prot
      Q6ZMN8
      Related
      ENSP00000478257.1, ENST00000614847.1
      Conserved Domains (1) summary
      pfam00134
      Location:156 → 247
      Cyclin_N; Cyclin, N-terminal domain

    3. NM_001287253.2 → NP_001274182.1  cyclin-I2 isoform 3

      See identical proteins and their annotated locations for NP_001274182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AC004775, AK131553, AW131382, BC144416
      UniProtKB/Swiss-Prot
      Q6ZMN8
      Conserved Domains (1) summary
      pfam00134
      Location:157 → 248
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      132747426..132756065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417523.1 → XP_047273479.1  cyclin-I2 isoform X3

    2. XM_047417522.1 → XP_047273478.1  cyclin-I2 isoform X2

    3. XM_047417521.1 → XP_047273477.1  cyclin-I2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      133267163..133275992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353138.1 → XP_054209113.1  cyclin-I2 isoform X3

    2. XM_054353137.1 → XP_054209112.1  cyclin-I2 isoform X2

    3. XM_054353136.1 → XP_054209111.1  cyclin-I2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMN8.1 GenPept UniProtKB/Swiss-Prot:Q6ZMN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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