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    CKLF chemokine like factor [ Homo sapiens (human) ]

    Gene ID: 51192, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CKLFprovided by HGNC
    Official Full Name
    chemokine like factorprovided by HGNC
    Primary source
    HGNC:HGNC:13253
    See related
    Ensembl:ENSG00000217555 MIM:616074; AllianceGenome:HGNC:13253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224
    Summary
    The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in appendix (RPKM 18.6), testis (RPKM 17.1) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CKLF in Genome Data Viewer
    Location:
    16q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66552563..66566287)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72346858..72360582)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66586466..66600190)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene brain expressed associated with NEDD4 1 Neighboring gene uncharacterized LOC124903698 Neighboring gene BEAN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66510981-66511522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66512063-66512603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66513685-66514224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66518060-66519040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66521703-66522203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66543229-66544204 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66545181-66546156 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66546157-66547132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66553931-66554431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10940 Neighboring gene thymidine kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10941 Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux. Chen C, et al. J Ethnopharmacol, 2021 Jan 10. PMID 32918990
    2. Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-κB /VCAM-1 pathway. Liu X, et al. FEBS Open Bio, 2020 Sep. PMID 32741140, Free PMC Article
    3. Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer. Dunne PD, et al. Oncotarget, 2016 Jun 14. PMID 27153559, Free PMC Article
    4. Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals. Zhang M, et al. Medicine (Baltimore), 2016 Mar. PMID 26986142, Free PMC Article
    5. Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Tao K, et al. J Huazhong Univ Sci Technolog Med Sci, 2016 Feb. PMID 26838743

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
      Title: CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
    2. Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.
      Title: Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.
    3. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.
      Title: Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.
    4. Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-kappaB /VCAM-1 pathway.
      Title: Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-κB /VCAM-1 pathway.
    5. CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.
      Title: CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.
    6. Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-kappaB pathway and regulating transporter mediated drug efflux.
      Title: Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux.
    7. Data indicate that leukocyte-infiltrate derived chemokine-like factor (CKLF) expression is a candidate biomarker of favorable prognosis.
      Title: Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer.
    8. CKLF1 expression was up-regulated in synovim from rheumatoid arthritis and ankylosing spondylitis patients.
      Title: Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
    9. expression elevated in the skin of keloid patients
      Title: Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals.
    10. role in the pathogenesis of psoriasis by promoting the proliferation of microvascular endothelial cells
      Title: Chemokine-like factor 1-derived C-terminal peptides induce the proliferation of dermal microvascular endothelial cells in psoriasis.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chemokine-like factor (CKLF; HSPC224) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of chemokine-like factor (CKLF) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough CKLF-CMTM1

    Readthrough gene: CKLF-CMTM1, Included gene: CMTM1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lymphocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in secretion by cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemokine-like factor
    Names
    chemokine-like factor 1
    chemokine-like factor 2
    chemokine-like factor 3
    chemokine-like factor 4
    transmembrane proteolipid

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040138.3 → NP_001035228.1  chemokine-like factor isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the coding region and 3' UTR, compared to variant 1. The encoded isoform (e) is shorter and contains a unique C-terminus, compared to isoform a.
      Source sequence(s)
      BU189908, DA113473, DA804889
      Consensus CDS
      CCDS45502.1
      UniProtKB/TrEMBL
      I7GPS8
      Related
      ENSP00000416678.2, ENST00000417030.2

    2. NM_016326.3 → NP_057410.1  chemokine-like factor isoform c

      See identical proteins and their annotated locations for NP_057410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two an in-frame exons in the coding region, compared to variant 1. It encodes a shorter isoform (c), also known as an isoform CKL3.
      Source sequence(s)
      AF135381, BU189908, DA113473
      Consensus CDS
      CCDS10806.1
      UniProtKB/Swiss-Prot
      Q9UBR5
      Related
      ENSP00000355417.4, ENST00000362093.4

    3. NM_016951.4 → NP_058647.1  chemokine-like factor isoform a

      See identical proteins and their annotated locations for NP_058647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (a), also known as an isoform CKLF2.
      Source sequence(s)
      AF135380
      Consensus CDS
      CCDS10807.1
      UniProtKB/Swiss-Prot
      C9JE38, Q9UBR5, Q9UHM7, Q9UHN8, Q9UI41
      UniProtKB/TrEMBL
      I7GPS8
      Related
      ENSP00000264001.5, ENST00000264001.9
      Conserved Domains (1) summary
      pfam01284
      Location:26 → 98
      MARVEL; Membrane-associating domain

    4. NM_181640.2 → NP_857591.1  chemokine-like factor isoform b

      See identical proteins and their annotated locations for NP_857591.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), also known as an isoform CKLF1.
      Source sequence(s)
      AF096895, BU189908, DA113473
      Consensus CDS
      CCDS10808.1
      UniProtKB/TrEMBL
      Q5BJH6
      Related
      ENSP00000264003.4, ENST00000351137.8

    5. NM_181641.2 → NP_857592.1  chemokine-like factor isoform d

      See identical proteins and their annotated locations for NP_857592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (d), also known as an isoform CKLF4.
      Source sequence(s)
      AF145216, BU189908, DA113473
      Consensus CDS
      CCDS10809.1
      UniProtKB/Swiss-Prot
      Q9UBR5
      Related
      ENSP00000290771.4, ENST00000345436.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66552563..66566287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72346858..72360582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040139.1: Suppressed sequence

      Description
      NM_001040139.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UBR5.1 GenPept UniProtKB/Swiss-Prot:Q9UBR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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