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    MIR100HG mir-100-let-7a-2-mir-125b-1 cluster host gene [ Homo sapiens (human) ]

    Gene ID: 399959, updated on 30-Apr-2024

    Summary

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    Official Symbol
    MIR100HGprovided by HGNC
    Official Full Name
    mir-100-let-7a-2-mir-125b-1 cluster host geneprovided by HGNC
    Primary source
    HGNC:HGNC:39522
    See related
    Ensembl:ENSG00000255248 MIM:615965; AllianceGenome:HGNC:39522
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGD1; lncRNA-N2; linc-NeD125
    Summary
    This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016]
    Expression
    Broad expression in ovary (RPKM 32.2), gall bladder (RPKM 20.3) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIR100HG in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (122028329..122422871, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (122057374..122452245, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (121899037..122293579, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984402 Neighboring gene VISTA enhancer hs872 Neighboring gene RNA, U6 small nuclear 256, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:121976285-121976785 Neighboring gene microRNA 125b-1 Neighboring gene microRNA let-7a-2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:122050835-122052034 Neighboring gene BH3-like motif containing, cell death inducer Neighboring gene microRNA 10526 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122067486-122068685 Neighboring gene microRNA 100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:122100557-122101387 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122244306-122244840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4007 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122292931-122294130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122312133-122312797 Neighboring gene RNA, U4atac small nuclear 10, pseudogene Neighboring gene RNA, U4atac small nuclear 5, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MIR100HG: a credible prognostic biomarker and an oncogenic lncRNA in gastric cancer. Li J, et al. Biosci Rep, 2019 Apr 30. PMID 30886062, Free PMC Article
    2. ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2. Su X, et al. Biomed Pharmacother, 2019 Jan. PMID 30551532
    3. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Wang S, et al. Cell Death Dis, 2018 Jul 24. PMID 30042378, Free PMC Article
    4. Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer. Peng J, et al. Mol Cancer Res, 2022 Jun 3. PMID 35247921
    5. Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells. Bevilacqua V, et al. RNA Biol, 2015. PMID 26480000, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MIR100HG affects the proliferation and metastasis of lung cancer cells through mediating the microRNA-5590-3p/DCBLD2 axis.
      Title: LncRNA MIR100HG affects the proliferation and metastasis of lung cancer cells through mediating the microRNA-5590-3p/DCBLD2 axis.
    2. A concise review on the role of MIR100HG in human disorders.
      Title: A concise review on the role of MIR100HG in human disorders.
    3. Constitutive beta-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer.
      Title: Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer.
    4. Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.
      Title: Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.
    5. The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. In conclusion, MIR100HG is a credible prognostic biomarker and functions as an oncogenic lncRNA in gastric cancer.
      Title: MIR100HG: a credible prognostic biomarker and an oncogenic lncRNA in gastric cancer.
    6. MIR100HG rs1816158 was associated with overall survival in oral cavity cancer. Expression of miR-100 was associated with overall survival in an independent cohort of head and neck squamous cell carcinoma (HNSCC) cases.
      Title: MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma.
    7. MIR100HG formed a triplex structure with p27. Through regulating the expression of p27, MIR100HG promoted cell proliferation in TNBC. Increased expression of MIR100HG was associated with poor prognosis.
      Title: LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci.
    8. We conclude that MIR100HG potentially serves as a binding platform for both HuR and its target mRNAs, thus modulating HuR-target mRNA interaction
      Title: MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs.
    9. ELK1-induced up-regulation of MIR100HG promoted osteosarcoma progression by epigenetically silencing LATS1 and LATS2.
      Title: ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2.
    10. TGF-beta induces MIR100HG lncRNA, encoding miR-100, let-7a and miR-125b that control pancreatic ductal adenocarcinoma tumorigenesis. Pro-tumorigenic miR-100 and miR-125b increase and anti-tumorigenic let-7a is unchanged, as TGF-beta also induces LIN28B. The induction of LIN28B results in the up-regulation of miR-100 and miR-125b, with let-7a unchanged despite being part of the same MIR100HG primary transcript.
      Title: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • adipogenesis down-regulated transcript 1
    • lncRNA neuronal 2
    • mir-100-let-7a-2 cluster host gene (non-protein coding)
    • neuronal differentiation lncRNA hosting miR-125

    Clone Names

    • FLJ11490, FLJ18351, FLJ34394, FLJ41953, DKFZp686L0115, DKFZp686J24156

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024430.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the reference variant.
      Source sequence(s)
      AK311309, AP000755, AP001924

    2. NR_137175.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000529823.2

    3. NR_137176.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as linc-NeD125) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, BC040599, BX538058

    4. NR_137177.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, BC040599, BX538058, BX647608
      Related
      ENST00000524376.2

    5. NR_137178.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter, differs in the 5' and 3' exon structure, and is shorter than variant 1.
      Source sequence(s)
      AP001924, BC089451

    6. NR_137179.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA861327

    7. NR_137180.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA788103, DA808613

    8. NR_137181.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000755, AP001924, DA153922

    9. NR_137182.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB485963, AP000755, AP001924
      Related
      ENST00000664908.1

    10. NR_137183.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA650430
      Related
      ENST00000656793.1

    11. NR_137184.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA659486

    12. NR_137185.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA474693, DA649890

    13. NR_137186.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA597554
      Related
      ENST00000660603.1

    14. NR_137187.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA027094, DA597554
      Related
      ENST00000648209.1

    15. NR_137188.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001359, AP001924, DA349788
      Related
      ENST00000650497.1

    16. NR_137189.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA769636
      Related
      ENST00000654519.1

    17. NR_137190.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DA532588
      Related
      ENST00000531071.6

    18. NR_137191.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924, DB248200
      Related
      ENST00000532890.6

    19. NR_137192.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP000755, AP001359, AP001835, AP001924
      Related
      ENST00000661848.1

    20. NR_137193.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP000755, AP001359, AP001924, KF459774
      Related
      ENST00000662950.1

    21. NR_137194.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001359, AP001924, KF459774
      Related
      ENST00000663296.1

    22. NR_137195.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000658364.1

    23. NR_137196.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AP001924
      Related
      ENST00000653167.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      122028329..122422871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      122057374..122452245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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    Research Materials