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    SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Gallus gallus (chicken) ]

    Gene ID: 396040, updated on 6-Jun-2024

    Summary

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    Official Symbol
    SMARCA2provided by CGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by CGNC
    Primary source
    CGNC:7728
    See related
    Ensembl:ENSGALG00010011808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    BRM
    Orthologs
    human mouse all
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    Genomic context

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    See SMARCA2 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (26827886..26938544)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (26827886..26938544)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108546 Neighboring gene uncharacterized LOC112530669 Neighboring gene uncharacterized LOC107052277 Neighboring gene very low density lipoprotein receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of cDNAs encoding chicken homologues of the yeast SNF2 and Drosophila Brahma proteins. Goodwin GH. Gene, 1997 Jan 3. PMID 9016949
    2. Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. Thaete C, et al. Hum Mol Genet, 1999 Apr. PMID 10072425

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable global transcription activator SNF2L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398355.1 → NP_001385284.1  probable global transcription activator SNF2L2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000089
      UniProtKB/TrEMBL
      A0A1D5PC01, A0A8V0YB44
      Related
      ENSGALP00010016181.1, ENSGALT00010028243.1
      Conserved Domains (8) summary
      cd05516
      Location:1378 → 1484
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:585 → 629
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:431 → 503
      HSA; domain in helicases and associated with SANT domains
      smart00951
      Location:170 → 204
      QLQ; QLQ is named after the conserved Gln, Leu, Gln motif
      PLN03142
      Location:716 → 1198
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:315 → 522
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:94 → 248
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18063
      Location:697 → 947
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2

    2. NM_205139.2 → NP_990470.2  probable global transcription activator SNF2L2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000089
      UniProtKB/TrEMBL
      A0A1D5PC01, A0A8V0YB44
      Related
      ENSGALP00010016187.1, ENSGALT00010028255.1
      Conserved Domains (8) summary
      cd05516
      Location:1378 → 1484
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:585 → 629
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:431 → 503
      HSA; domain in helicases and associated with SANT domains
      smart00951
      Location:170 → 204
      QLQ; QLQ is named after the conserved Gln, Leu, Gln motif
      PLN03142
      Location:716 → 1198
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:315 → 522
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:94 → 248
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18063
      Location:697 → 947
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      26827886..26938544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046905259.1 → XP_046761215.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    2. XM_046905256.1 → XP_046761212.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    3. XM_046905253.1 → XP_046761209.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    4. XM_046905254.1 → XP_046761210.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    5. XM_040655435.2 → XP_040511369.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44
      Conserved Domains (10) summary
      cd05516
      Location:1380 → 1486
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:433 → 505
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:718 → 1200
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:317 → 524
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:56 → 333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15822
      Location:100 → 160
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      cd18063
      Location:699 → 949
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2
      pfam07533
      Location:587 → 629
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1258 → 1324
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    6. XM_046905255.1 → XP_046761211.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    7. XM_025144681.3 → XP_025000449.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44
      Conserved Domains (10) summary
      cd05516
      Location:1380 → 1486
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:433 → 505
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:718 → 1200
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:317 → 524
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:56 → 333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15822
      Location:100 → 160
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      cd18063
      Location:699 → 949
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2
      pfam07533
      Location:587 → 629
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1258 → 1324
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    8. XM_046905258.1 → XP_046761214.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    9. XM_040655434.2 → XP_040511368.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44
      Conserved Domains (10) summary
      cd05516
      Location:1380 → 1486
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:433 → 505
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:718 → 1200
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:317 → 524
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:56 → 333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15822
      Location:100 → 160
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      cd18063
      Location:699 → 949
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2
      pfam07533
      Location:587 → 629
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1258 → 1324
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    10. XM_046905252.1 → XP_046761208.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YB44

    11. XM_046905257.1 → XP_046761213.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    12. XM_040655436.2 → XP_040511370.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44
      Conserved Domains (10) summary
      cd05516
      Location:1380 → 1486
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:433 → 505
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:718 → 1200
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG4942
      Location:317 → 524
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:56 → 333
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15822
      Location:100 → 160
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      cd18063
      Location:699 → 949
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2
      pfam07533
      Location:587 → 629
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1258 → 1324
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    13. XM_040655439.2 → XP_040511373.1  probable global transcription activator SNF2L2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5NTB4
      Conserved Domains (8) summary
      cd05516
      Location:1360 → 1466
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:567 → 611
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:413 → 485
      HSA; domain in helicases and associated with SANT domains
      smart00951
      Location:150 → 184
      QLQ; QLQ is named after the conserved Gln, Leu, Gln motif
      PLN03142
      Location:698 → 1180
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      PHA03378
      Location:77 → 230
      PHA03378; EBNA-3B; Provisional
      COG4942
      Location:297 → 504
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd18063
      Location:679 → 929
      DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2

    14. XM_046905260.1 → XP_046761216.1  probable global transcription activator SNF2L2 isoform X4

    15. XM_046905261.1 → XP_046761217.1  probable global transcription activator SNF2L2 isoform X5

    16. XM_015280074.3 → XP_015135560.1  probable global transcription activator SNF2L2 isoform X6

      Conserved Domains (2) summary
      cd05516
      Location:86 → 192
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:37 → 99
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    17. XM_046905262.1 → XP_046761218.1  probable global transcription activator SNF2L2 isoform X7

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      26827886..26938544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046934835.1 → XP_046790791.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    2. XM_046934831.1 → XP_046790787.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    3. XM_046934827.1 → XP_046790783.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    4. XM_046934828.1 → XP_046790784.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    5. XM_046934830.1 → XP_046790786.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    6. XM_046934829.1 → XP_046790785.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    7. XM_046934825.1 → XP_046790781.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    8. XM_046934834.1 → XP_046790790.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    9. XM_046934826.1 → XP_046790782.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    10. XM_046934824.1 → XP_046790780.1  probable global transcription activator SNF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YB44

    11. XM_046934832.1 → XP_046790788.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    12. XM_046934833.1 → XP_046790789.1  probable global transcription activator SNF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YB44

    13. XM_046934836.1 → XP_046790792.1  probable global transcription activator SNF2L2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5NTB4

    14. XM_046934837.1 → XP_046790793.1  probable global transcription activator SNF2L2 isoform X4

    15. XM_046934838.1 → XP_046790794.1  probable global transcription activator SNF2L2 isoform X5

    16. XM_046934839.1 → XP_046790795.1  probable global transcription activator SNF2L2 isoform X6

    17. XM_046934840.1 → XP_046790796.1  probable global transcription activator SNF2L2 isoform X7

    Nucleotide Protein
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