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    Brd8dc BRD8 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 271508, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Brd8dcprovided by MGI
    Official Full Name
    BRD8 domain containingprovided by MGI
    Primary source
    MGI:MGI:3045347
    See related
    Ensembl:ENSMUSG00000049357 AllianceGenome:MGI:3045347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933408B17Rik
    Summary
    Predicted to be involved in histone acetylation. Predicted to be part of NuA4 histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 1.6), CNS E11.5 (RPKM 1.5) and 20 other tissues See more
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    Genomic context

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    See Brd8dc in Genome Data Viewer
    Location:
    18 B1; 18 18.69 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34712899..34730521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34579846..34597468, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene predicted gene, 41688 Neighboring gene STARR-positive B cell enhancer ABC_E4242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34784160-34784348 Neighboring gene STARR-positive B cell enhancer ABC_E963 Neighboring gene kinesin family member 20A Neighboring gene CDC23 cell division cycle 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC271508

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358301.1 → NP_001345230.1  uncharacterized protein LOC271508 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074335
      UniProtKB/TrEMBL
      Q8CDF1
      Conserved Domains (1) summary
      cl02556
      Location:146 → 206
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    2. NM_001358302.1 → NP_001345231.1  uncharacterized protein LOC271508 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074335
      UniProtKB/TrEMBL
      Q8CDF1
      Conserved Domains (1) summary
      cd05507
      Location:146 → 229
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

    3. NM_177773.4 → NP_808441.2  uncharacterized protein LOC271508 isoform 1

      See identical proteins and their annotated locations for NP_808441.2

      Status: VALIDATED

      Source sequence(s)
      AC074335
      Consensus CDS
      CCDS37758.1
      UniProtKB/TrEMBL
      G3X9B4, Q8CDF1
      Related
      ENSMUSP00000054234.3, ENSMUST00000056932.9
      Conserved Domains (1) summary
      cd05507
      Location:160 → 259
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

    RNA

    1. NR_152398.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074335
      Related
      ENSMUST00000129566.2

    2. NR_152399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074335

    3. NR_152400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074335

    4. NR_152401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074335

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34712899..34730521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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