Glra3 glycine receptor, alpha 3 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glra3provided by MGI
Official Full Name: glycine receptor, alpha 3 subunitprovided by MGI
Primary source: MGI:MGI:95749
See related: Ensembl:ENSMUSG00000038257 AllianceGenome:MGI:95749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable glycine-gated chloride ion channel activity. Predicted to contribute to extracellularly glycine-gated chloride channel activity and glycine binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within glutamate receptor clustering. Located in GABA-ergic synapse and glutamatergic synapse. Is active in glycinergic synapse. Is expressed in central nervous system and eye. Orthologous to human GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 B2; 8 29.69 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (56393454..56583111)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (55940418..56130070)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A phospho-deficient alpha3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons.
Title: A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons.
A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia.
Title: A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia.
This experiments identify the alpha3 subunit of the glycine receptor as a target of modulation in a mouse model of Rett syndrome.
Title: Breathing disturbances in a model of Rett syndrome: A potential involvement of the glycine receptor α3 subunit?
alpha2 and alpha3 GlyRs are present in various regions of the forebrain and that alpha3 GlyRs specifically participate in tonic inhibition in the striatum and prefrontal cortex.
Title: Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.
loss of alpha3-GlyRs in mice compromises suprathreshold auditory nerve activity, but not outer hair cell function
Title: Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function.
GlyRalpha3 KO animals showed significantly impaired prepulse inhibition of the auditory startle response and changes in auditory brainstem response.
Title: Deficit in acoustic signal-in-noise detection in glycine receptor α3 subunit knockout mice.
Findings suggest that trigeminal primary afferent boutons receive presynaptic modulation via homomeric, extrasynaptic glycine receptor subunit alpha 3, and that different subtypes of glycine receptors may be involved in pre- and postsynaptic inhibition.
Title: Expression of glycine receptor alpha 3 in the rat trigeminal neurons and central boutons in the brainstem.
presynaptic glycine release in the hypoglossal nucleus is partially depending on GlyR alpha3.
Title: Presynaptic facilitation of glycinergic mIPSC is reduced in mice lacking α3 glycine receptor subunits.
The postsynaptic clusters of a3-containing GlyRs werelocated to efferent synapses of the medial and lateral olivocochlear bundle in the murine organ of Corti beyond the onset of hearing.
Title: Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
Both GlyRalpha2 and GlyRalpha3 modulate local receptive fields in the retina: GlyRalpha3 mediates serial inhibition, whereas GlyRalpha2 participates in crossover inhibition.
Title: Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Glra3 (e-PCR), detects polymorphism
- UniSTS:496044

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables glycine-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
part_of glycine-gated chloride channel complex	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine receptor subunit alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368774.2 → NP_001355703.1 glycine receptor subunit alpha-3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC117729, AC119900

Conserved Domains (1) summary

TIGR00860
Location:12 → 436

LIC; Cation transporter family protein
NM_080438.4 → NP_536686.3 glycine receptor subunit alpha-3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC117729, AC119900

Consensus CDS

CCDS40340.1

UniProtKB/Swiss-Prot

Q7TSQ2, Q91XP5

Related

ENSMUSP00000000275.9, ENSMUST00000000275.10

Conserved Domains (1) summary

TIGR00860
Location:12 → 451

LIC; Cation transporter family protein