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    NEDD8-MDP1 NEDD8-MDP1 readthrough [ Homo sapiens (human) ]

    Gene ID: 100528064, updated on 3-Apr-2024

    Summary

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    Official Symbol
    NEDD8-MDP1provided by HGNC
    Official Full Name
    NEDD8-MDP1 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:39551
    See related
    Ensembl:ENSG00000255526 AllianceGenome:HGNC:39551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in kidney (RPKM 46.4), fat (RPKM 46.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See NEDD8-MDP1 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24213943..24232367, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18412319..18430739, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24683149..24701573, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene magnesium dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24710068-24710597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8200 Neighboring gene TERF1 interacting nuclear factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    2. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
    3. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Shen R, et al. Transl Neurodegener, 2020 Jun 18. PMID 32552912, Free PMC Article
    4. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
    5. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough NEDD8-MDP1

    Included genes: NEDD8, MDP1

    Homology

    General protein information

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    Preferred Names
    NEDD8-MDP1 protein
    Names
    NEDD8-MDP1 read-through transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051059.1 RefSeqGene

      Range
      5001..23449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199823.3 → NP_001186752.1  NEDD8-MDP1 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
      Source sequence(s)
      AL096870, DN993851
      UniProtKB/TrEMBL
      E9PL57
      Related
      ENSP00000431482.1, ENST00000534348.5
      Conserved Domains (3) summary
      smart00213
      Location:1 → 50
      UBQ; Ubiquitin homologues
      pfam12689
      Location:51 → 177
      Acid_PPase; Acid Phosphatase
      cl00155
      Location:1 → 51
      UBQ; Ubiquitin-like proteins

    2. NM_001412116.1 → NP_001399045.1  NEDD8-MDP1 protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      CP068264

    RNA

    1. NR_137630.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL096870, CB070148

    2. NR_137631.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL096870, FY211956

    3. NR_137632.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL096870, FY212610
      Related
      ENST00000604306.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24213943..24232367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      514921..533345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18412319..18430739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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