Acute ethanol administration effect on Toll-like receptor 3 signaling in macrophages
Summary:
Analysis of peritoneal macrophages from 8 to12 week-old C57BL/6xC3H females treated with 100 ug poly(I:C) and 6 g/kg ethanol. Poly(I:C) mimics viral dsRNA by binding Toll-like receptor 3. Results provide insight into the suppression of innate immunity by ethanol.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Pruett SB, Schwab C, Zheng Q, Fan R. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J Immunol 2004 Aug 15;173(4):2715-24. PMID: 15294990
