Amyloid precursor protein mutant overexpression in strain resistant to neuronal cell loss
Summary:
Expression profiling of brain left hippocampi from 12 month old Tg2576 transgenics overexpressing the amyloid precursor protein with the Swedish mutation (APPSw). APPSw linked to the early-onset Alzheimer's disease. Tg2576 express neuroprotective genes that prevent neuronal cell loss.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Stein TD, Anders NJ, DeCarli C, Chan SL et al. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 2004 Sep 1;24(35):7707-17. PMID: 15342738
