Embryonic fibroblast response to ectopic expression of transcription factors Oct4, Sox2, Klf4, c-Myc: time course
Summary:
Analysis of embryonic fibroblasts (MEFs) infected with retroviruses encoding four transcription factors (Oct4, Sox2, Klf4 and c-Myc) and sampled at day 1, 2, 3, 4, 5, 6 and 8. Results provide insight into molecular mechanisms underlying the reprogramming of MEFs into induced pluripotent stem cells.
Koga M, Matsuda M, Kawamura T, Sogo T et al. Foxd1 is a mediator and indicator of the cell reprogramming process. Nat Commun 2014;5:3197. PMID: 24496101
