Tumor-infiltrating CD8 T cells silenced for negative regulators of T cells
Summary:
Analysis of CD8 T cells that were transduced with shRNAs targeting inhibitors of T-cell function, adoptively transferred into B16 tumor-bearing mice, and purified from spleen or tumor 7 days later. Results provide insight into molecular mechanisms blocking cytotoxic T cell infiltration into tumors.
Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature 2014 Feb 6;506(7486):52-7. PMID: 24476824
