Analysis of heart from adults deficient for peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) α and PGC-1β. Adult PGC-1α/β deficient heart did not exhibit abnormal mitochondrial dynamics or heart failure. Results provide insight into role of PGC-1 coactivators in adult heart.
Martin OJ, Lai L, Soundarapandian MM, Leone TC et al. A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res 2014 Feb 14;114(4):626-36. PMID: 24366168