Analysis of Trp53-null tumors arising from Tgfb1+/- hosts cleared of mammary gland epithelia, irradiated, then transplanted with nonmalignant Trp53-null mammary tissue. TGF-β drives EMT and is highly induced by IR. Results provide insight into host biology contributions to radiation carcinogenesis.
Nguyen DH, Fredlund E, Zhao W, Perou CM et al. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res 2013 Mar 15;19(6):1353-62. PMID: 23339125
