Pimecrolimus and betamethasone valerate effects on lesional skin of actopic dermatitis
Summary:
Analysis of skin biopsies from AD patients treated with pimecrolimus on 1 upper limb and betamethasone (BM) on the other upper limb. BM is clinically more effective but does not restore the skin barrier, compared to pimecrolimus. Results provide insight into mechanisms of action of both substances.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Jensen JM, Scherer A, Wanke C, Bräutigam M et al. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. Allergy 2012 Mar;67(3):413-23. PMID: 22142306
