Pancreatic CD45+ immune cells from NOD model of type 1 diabetes
Summary:
Analysis of pancreatic CD45+ cells from 10 week-old NOD females MRI-scanned to noninvasively visualize effects of pancreatic-islet inflammation. All NOD juveniles develop insulitis but vary highly in their progression to diabetes. Results provide insight into molecular basis of disease progression.
Fu W, Wojtkiewicz G, Weissleder R, Benoist C et al. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol 2012 Feb 26;13(4):361-8. PMID: 22366893
