DataSet Record GDS4337: Expression Profiles Data Analysis Tools Sample Subsets
Title: Type 2 diabetic and hyperglycemic pancreatic islets
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Summary: Analysis of pancreatic islets from type 2 diabetes (T2D) and non-diabetic cadaver donors. Glycemic control (HbA1c) levels also measured from the same individuals (normoglycemic: HbA1c < 6%; hyperglycemic: HbA1c ≥ 6%). Results provided insight into molecular basis of islet dysfunction in T2D.
Organism: Homo sapiens
Platform: GPL6244: [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citations:
  • Taneera J, Lang S, Sharma A, Fadista J et al. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab 2012 Jul 3;16(1):122-34. PMID: 22768844
  • Taneera J, Fadista J, Ahlqvist E, Zhang M et al. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Mol Cell Endocrinol 2013 Aug 15;375(1-2):35-42. PMID: 23707792
  • Kanatsuna N, Taneera J, Vaziri-Sani F, Wierup N et al. Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. J Biol Chem 2013 Oct 4;288(40):29013-23. PMID: 23935095
  • Hänzelmann S, Wang J, Güney E, Tang Y et al. Thrombin stimulates insulin secretion via protease-activated receptor-3. Islets 2015;7(4):e1118195. PMID: 26742564
Reference Series: GSE38642 Sample count: 63
Value type: transformed count Series published: 2012/07/05