Interleukin-2 null effect on the regulatory T cell-deficient scurfy model of autoimmune disease: CD4+ T-cells
Summary:
Analysis of CD4+ T cells purified from pooled peripheral lymph nodes of scurfy (Sf) mice deficient in interleukin-2. Sf.Il2-/- mice develop liver inflammation, but not inflammation of skin and lung, seen in Sf mice. Results provide insight into role of IL2 in multiorgan inflammation in Sf mice.
Sharma R, Sharma PR, Kim YC, Leitinger N et al. IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation. J Immunol 2011 Jan 15;186(2):1268-78. PMID: 21169543
