Postmenopausal estrogen receptor α-positive breast tumor with PIK3CA mutation
Summary:
Analysis of estrogen receptor α-positive (ERα+) breast tumors with phosphatidylinositol 3-kinase catalytic subunit (PIK3CA) mutation. PIK3CA mutations have been observed in 30% to 40% of ERα-positive breast tumors. Results provide insight into the role of PIK3CA mutations in breast tumorigenesis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Cizkova M, Cizeron-Clairac G, Vacher S, Susini A et al. Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway. PLoS One 2010 Dec 30;5(12):e15647. PMID: 21209903
