Analysis of heart from Gata4-S105A knock-in mutants (MAPK phosphorylation site at serine 105 mutated to alanine) treated with phenylephrine. The mutants showed a compromised stress response of the myocardium. Results provide insight into molecular basis of stress-related cardiac hypertrophy.
van Berlo JH, Elrod JW, Aronow BJ, Pu WT et al. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A 2011 Jul 26;108(30):12331-6. PMID: 21746915
