Rod-derived cone viability factor deficiency effect on the retina
Summary:
Analysis of retinas from animals lacking the rod-derived cone viability factor (RdCVF). RdCVF is encoded by the Nxnl1 gene. Cone loss in animal models of retinitis pigmentosa is reduced by RdCVF protein therapy. Results provide insight into the physiological role of RdCVF in the retina.
Cronin T, Raffelsberger W, Lee-Rivera I, Jaillard C et al. The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ 2010 Jul;17(7):1199-210. PMID: 20139892
