p300 genetic reduction model of Rubinstein-Taybi syndrome: hippocampus
Summary:
Analysis of hippocampi from heterozygous p300 deletion animals. A small percentage of cases of Rubinstein-Taybi syndrome (RSTS) is caused by p300 mutations. Results provide insight in the contribution of p300 to RSTS pathoetiology.
Viosca J, Lopez-Atalaya JP, Olivares R, Eckner R et al. Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol Dis 2010 Jan;37(1):186-94. PMID: 19822209
