DataSet Record GDS3440: Expression Profiles Data Analysis Tools Sample Subsets
Title: Aortic endothelial cell response to dominant negative PPAR gamma expression in vitro
Cluster AnalysisGDS3440 Cluster Image
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Summary: Analysis of cultured endothelial cells expressing the dominant negative V290M PPAR gamma mutant protein. PPAR gamma exerts anti-inflammatory and antioxidant effects in the vascular endothelium. Results provide insight into the molecular basis of PPAR gamma's protective action in the vasculature.
Organism: Mus musculus
Platform: GPL1261: [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Citations:
  • Beyer AM, de Lange WJ, Halabi CM, Modrick ML et al. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res 2008 Sep 12;103(6):654-61. PMID: 18676352
  • Jin H, Gebska MA, Blokhin IO, Wilson KM et al. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. Arterioscler Thromb Vasc Biol 2015 Apr;35(4):838-44. PMID: 25675995
Reference Series: GSE11870 Sample count: 6
Value type: count Series published: 2008/07/23