Analysis of embryonic day 11.5 hearts inactivated for Dicer, an RNase III endonuclease essential for processing of pre-microRNAs (miRNAs) into the mature form. The mutants died from cardiac failure by E12.5. Results provide insight into the role of miRNA function during cardiac development.
Zhao Y, Ransom JF, Li A, Vedantham V et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007 Apr 20;129(2):303-17. PMID: 17397913