Breast cancer formation in WAP-SVT/t transgenic animals
Summary:
Analysis of mammary gland segments from WAP–SVT/t transgenic animals. These animals selectively synthesize the SV40 T/t antigen in mammary gland epithelial (ME) cells and develop breast cancer after the first lactation. Results provide insight into the role of SV40 T/t antigen in tumor formation.
Klein A, Guhl E, Zollinger R, Tzeng YJ et al. Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals. J Mol Med (Berl) 2005 May;83(5):362-76. PMID: 15662539
