Bone morphogenic protein receptor 2 inactivation in smooth muscle effect on the lung: time course
Summary:
Analysis of lungs 1 or 8 weeks following induction in smooth muscle of a dominant negative mutant form of type 2 bone morphogenic protein receptor (BMPR2). Results provide insight into the pathogenesis of hereditary pulmonary arterial hypertension (PAH), a disorder associated with BMPR2 mutations.
Tada Y, Majka S, Carr M, Harral J et al. Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol 2007 Jun;292(6):L1556-63. PMID: 17369292
