Analysis of 14 tumor biopsies from children affected by alveolar rhabdomyosarcoma (ARMS). Seven patients were positive for the PAX3-FKHR fusion gene, which indicates an unfavorable prognosis. Results identify expression signatures that differentiate PAX3-FKHR positive from PAX3-FKHR negative ARMS.
De Pittà C, Tombolan L, Albiero G, Sartori F et al. Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors. Int J Cancer 2006 Jun 1;118(11):2772-81. PMID: 16381018
