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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 1
2012 2
2013 1
2014 2
2015 2
2016 4
2017 2
2018 2
2019 2
2020 2
2024 0

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15 results

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Page 1
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP. Chattopadhyay C, et al. Cancer. 2016 Aug 1;122(15):2299-312. doi: 10.1002/cncr.29727. Epub 2016 Mar 15. Cancer. 2016. PMID: 26991400 Free PMC article. Review.
Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapies despite the routine exclusion of patients with uveal melanoma from clinical trials. Clinical trials directed at uveal …
Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapi …
BAP1: Not just a BRCA1-associated protein.
Louie BH, Kurzrock R. Louie BH, et al. Cancer Treat Rev. 2020 Nov;90:102091. doi: 10.1016/j.ctrv.2020.102091. Epub 2020 Aug 20. Cancer Treat Rev. 2020. PMID: 32877777 Free PMC article. Review.
BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, p …
BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizin …
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL. Kaliki S, et al. Eye (Lond). 2017 Feb;31(2):241-257. doi: 10.1038/eye.2016.275. Epub 2016 Dec 2. Eye (Lond). 2017. PMID: 27911450 Free PMC article. Review.
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either …
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most commo …
Melanoma genetics.
Read J, Wadt KA, Hayward NK. Read J, et al. J Med Genet. 2016 Jan;53(1):1-14. doi: 10.1136/jmedgenet-2015-103150. Epub 2015 Sep 3. J Med Genet. 2016. PMID: 26337759 Review.
Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma risk genes is an important component of disease occurrence. Susceptibility for some families is due to mutation in one of the …
Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma …
Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma.
Rossi E, Schinzari G, Maiorano BA, Pagliara MM, Di Stefani A, Bria E, Peris K, Blasi MA, Tortora G. Rossi E, et al. Int J Mol Sci. 2019 Oct 31;20(21):5447. doi: 10.3390/ijms20215447. Int J Mol Sci. 2019. PMID: 31683701 Free PMC article. Review.
CjM is commonly characterized by mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF), neurofibromin 1 (NF1) and telomerase reverse transcriptase (TERT), high expression of mammalian target of rapamycin (mTOR) and heat shock protein 90 (HSP90), frequent phosp …
CjM is commonly characterized by mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF), neurofibromin 1 (NF1) and telome …
Uveal Melanoma Risk Factors: A Systematic Review of Meta-Analyses.
Nayman T, Bostan C, Logan P, Burnier MN Jr. Nayman T, et al. Curr Eye Res. 2017 Aug;42(8):1085-1093. doi: 10.1080/02713683.2017.1297997. Epub 2017 May 11. Curr Eye Res. 2017. PMID: 28494168 Review.
The following significant risk factors were identified: atypical cutaneous nevi (OR 2.82, 95% CI 1.10-7.26), welding (OR 2.05, 95% CI 1.20-3.51), occupational cooking (OR 1.81, 95% CI 1.33-2.46), fair skin color (OR 1.80, 95% CI 1.31-2.47 …
The following significant risk factors were identified: atypical cutaneous nevi (OR 2.82, 95% CI 1.10-7.26), welding (OR 2.05, 95% CI …
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA. Murali R, et al. Pathology. 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. Pathology. 2013. PMID: 23277170 Review.
Germline mutations of BAP1 confer increased susceptibility for the development of several tumours, including uveal melanoma, epithelioid atypical Spitz tumours, cutaneous melanoma, and mesothelioma. ...Somatic BAP1 mutations are seen in cutaneous melanocytic …
Germline mutations of BAP1 confer increased susceptibility for the development of several tumours, including uveal melanoma …
Variability of Bad Prognosis in Uveal Melanoma.
Shao YF, Echegaray JJ, Singh N, Singh AD. Shao YF, et al. Ophthalmol Retina. 2019 Feb;3(2):186-193. doi: 10.1016/j.oret.2018.09.007. Epub 2018 Sep 21. Ophthalmol Retina. 2019. PMID: 31014770 Review.
TOPIC: Survival of patients with uveal melanoma classified to have a bad prognosis. CLINICAL RELEVANCE: To explore reasons for reported variability in survival of patients with uveal melanoma classified to have a bad prognosis. ...Only studies reportin …
TOPIC: Survival of patients with uveal melanoma classified to have a bad prognosis. CLINICAL RELEVANCE: To explore reasons for …
Genetic determinants of uveal melanoma.
Couturier J, Saule S. Couturier J, et al. Dev Ophthalmol. 2012;49:150-165. doi: 10.1159/000328270. Epub 2011 Oct 21. Dev Ophthalmol. 2012. PMID: 22042019 Review.
Uveal melanoma (UM) arises from neural crest-derived melanocytes of the choroid and the ciliary body. About 50% of patients develop metastatic disease despite efficient control of the primary tumor. For about 15 years, cytogenetic and, recently, genome-wide a …
Uveal melanoma (UM) arises from neural crest-derived melanocytes of the choroid and the ciliary body. About 50% of patients de …
Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing.
van Poppelen NM, de Bruyn DP, Bicer T, Verdijk R, Naus N, Mensink H, Paridaens D, de Klein A, Brosens E, Kiliҫ E. van Poppelen NM, et al. Int J Mol Sci. 2020 Dec 30;22(1):336. doi: 10.3390/ijms22010336. Int J Mol Sci. 2020. PMID: 33396957 Free PMC article. Review.
Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival melanoma. These malignancies derive from melanocytes in the uveal tract or conjunctiva. The genetic profiles of these different entities differ from each other. In uveal m …
Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival melanoma. These malignancies derive from …
15 results