Abstract
Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet beta-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIP/PAP-RS-REG I alpha-REG I beta-ptel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute-Phase Proteins / genetics
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Antigens, Neoplasm*
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Base Sequence
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Biomarkers, Tumor*
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Calcium-Binding Proteins / genetics*
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Chromosome Mapping
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Chromosomes, Artificial, Yeast
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Chromosomes, Human, Pair 2*
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Genomic Library
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Humans
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In Situ Hybridization, Fluorescence
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Islets of Langerhans / growth & development
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Lectins, C-Type*
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Lithostathine
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Molecular Sequence Data
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Multigene Family*
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Nerve Tissue Proteins*
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Pancreatitis-Associated Proteins
Substances
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Acute-Phase Proteins
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Antigens, Neoplasm
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Biomarkers, Tumor
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Calcium-Binding Proteins
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Lectins, C-Type
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Lithostathine
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Nerve Tissue Proteins
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Pancreatitis-Associated Proteins
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REG1A protein, human
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REG1B protein, human
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REG3A protein, human