Abstract
A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Amidohydrolases / antagonists & inhibitors*
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Amidohydrolases / metabolism
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Cannabinoid Receptor Modulators / metabolism
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Carbamates / chemical synthesis
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Carbamates / chemistry*
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Carbamates / pharmacology
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Kinetics
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Oximes / chemistry*
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Structure-Activity Relationship
Substances
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Cannabinoid Receptor Modulators
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Carbamates
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Enzyme Inhibitors
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Oximes
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Amidohydrolases
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fatty-acid amide hydrolase