PubMed (GeneRIF) for id: 51185

Year	Number of Results
2004	1
2007	1
2008	2
2010	1
2011	2
2012	3
2013	8
2014	9
2015	8
2016	15
2017	3
2018	5
2019	7
2020	16
2021	8
2022	3
2023	1
2024	1

1

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.

Hatakeyama K, Kikushige Y, Ishihara D, Yamamoto S, Kawano G, Tochigi T, Miyamoto T, Sakoda T, Christoforou A, Kunisaki Y, Fukata M, Kato K, Ito T, Handa H, Akashi K. Hatakeyama K, et al. Blood Adv. 2024 Feb 13;8(3):785-796. doi: 10.1182/bloodadvances.2023010080. Blood Adv. 2024. PMID: 38163319 Free PMC article.

2

Incidence of cereblon protein in intensive care patients: a cross-sectional study.

Ayvat P, Diniz G, Gulmez H, Arslan Yurtlu D, Asar K, Katircioglu K, Ece C, Sofuoglu Z. Ayvat P, et al. Eur Rev Med Pharmacol Sci. 2023 Jul;27(13):6081-6091. doi: 10.26355/eurrev_202307_32962. Eur Rev Med Pharmacol Sci. 2023. PMID: 37458657 Free article.

3

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.

Ichikawa S, Flaxman HA, Xu W, Vallavoju N, Lloyd HC, Wang B, Shen D, Pratt MR, Woo CM. Ichikawa S, et al. Nature. 2022 Oct;610(7933):775-782. doi: 10.1038/s41586-022-05333-5. Epub 2022 Oct 19. Nature. 2022. PMID: 36261529 Free PMC article.

4

CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells.

Kim MJ, Lee JS, Kim JY, Choi B, Son J, Min Y, Jeong SK, Kim DH, Lee JS, Chun E, Lee KY. Kim MJ, et al. Clin Transl Med. 2022 Sep;12(9):e1050. doi: 10.1002/ctm2.1050. Clin Transl Med. 2022. PMID: 36164994 Free PMC article. No abstract available.

5

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.

Yamanaka S, Horiuchi Y, Matsuoka S, Kido K, Nishino K, Maeno M, Shibata N, Kosako H, Sawasaki T. Yamanaka S, et al. Nat Commun. 2022 Jan 10;13(1):183. doi: 10.1038/s41467-021-27818-z. Nat Commun. 2022. PMID: 35013300 Free PMC article.

6

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.

Shimizu N, Asatsuma-Okumura T, Yamamoto J, Yamaguchi Y, Handa H, Ito T. Shimizu N, et al. Commun Biol. 2021 Nov 11;4(1):1277. doi: 10.1038/s42003-021-02801-y. Commun Biol. 2021. PMID: 34764413 Free PMC article.

7

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.

Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. Shen C, et al. Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z. Nat Commun. 2021. PMID: 34489457 Free PMC article.

8

Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation.

Fionda C, Stabile H, Molfetta R, Kosta A, Peruzzi G, Ruggeri S, Zingoni A, Capuano C, Soriani A, Paolini R, Gismondi A, Cippitelli M, Santoni A. Fionda C, et al. Eur J Immunol. 2021 Nov;51(11):2607-2617. doi: 10.1002/eji.202149269. Epub 2021 Sep 18. Eur J Immunol. 2021. PMID: 34392531 Free PMC article.

9

Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs.

Jones JR, Barber A, Le Bihan YV, Weinhold N, Ashby C, Walker BA, Wardell CP, Wang H, Kaiser MF, Jackson GH, Davies FE, Chopra R, Morgan GJ, Pawlyn C. Jones JR, et al. Leukemia. 2021 Oct;35(10):3017-3020. doi: 10.1038/s41375-021-01373-4. Epub 2021 Aug 9. Leukemia. 2021. PMID: 34373585 Free PMC article. No abstract available.

10

Cereblon enhancer methylation and IMiD resistance in multiple myeloma.

Haertle L, Barrio S, Munawar U, Han S, Zhou X, Vogt C, Fernández RA, Bittrich M, Ruiz-Heredia Y, Da Viá M, Zovko J, Garitano-Trojaola A, Bolli N, Ruckdeschel A, Stühmer T, Chatterjee M, Kull M, Krönke J, Agirre X, Martin-Subero JI, Raab P, Einsele H, Rasche L, Martinez-Lopez J, Haaf T, Kortüm KM. Haertle L, et al. Blood. 2021 Nov 4;138(18):1721-1726. doi: 10.1182/blood.2020010452. Blood. 2021. PMID: 34115836 Free PMC article.

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