PubMed (GeneRIF) for id: 18646

Year	Number of Results
2002	8
2003	8
2004	8
2005	12
2006	5
2007	3
2008	3
2009	8
2010	6
2011	7
2012	7
2013	8
2014	8
2015	9
2016	5
2017	3
2018	3
2019	1
2020	3
2022	1
2024	0

1

Caspase-7 activates ASM to repair gasdermin and perforin pores.

Nozaki K, Maltez VI, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA. Nozaki K, et al. Nature. 2022 Jun;606(7916):960-967. doi: 10.1038/s41586-022-04825-8. Epub 2022 Jun 15. Nature. 2022. PMID: 35705808 Free PMC article.

2

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD.

Wang Q, Li D, Zhu J, Zhang M, Zhang H, Cao G, Zhu L, Shi Q, Hao J, Wen Q, Liu Z, Yang H, Yin Z. Wang Q, et al. Front Immunol. 2020 May 22;11:846. doi: 10.3389/fimmu.2020.00846. eCollection 2020. Front Immunol. 2020. PMID: 32528465 Free PMC article.

3

Impaired B Cell Function in Mice Lacking Perforin-2.

Frasca D, Diaz A, Romero M, Vazquez T, Strbo N, Romero L, McCormack RM, Podack ER, Blomberg BB. Frasca D, et al. Front Immunol. 2020 Feb 27;11:328. doi: 10.3389/fimmu.2020.00328. eCollection 2020. Front Immunol. 2020. PMID: 32180773 Free PMC article.

4

Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2.

Prinz D, Klein K, List J, Knab VM, Menzl I, Leidenfrost N, Heller G, Polić B, Putz EM, Witalisz-Siepracka A, Sexl V, Gotthardt D. Prinz D, et al. Eur J Immunol. 2020 Jun;50(6):880-890. doi: 10.1002/eji.201948222. Epub 2020 Feb 20. Eur J Immunol. 2020. PMID: 32052406 Free PMC article.

5

CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier.

Liu Z, Zhang H, Xia H, Wang B, Zhang R, Zeng Q, Guo L, Shen K, Wang B, Zhong Y, Li Z, Sun G. Liu Z, et al. Biochem Biophys Res Commun. 2019 Apr 30;512(2):367-372. doi: 10.1016/j.bbrc.2019.03.002. Epub 2019 Mar 18. Biochem Biophys Res Commun. 2019. PMID: 30894275

6

Impaired immune surveillance accelerates accumulation of senescent cells and aging.

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V. Ovadya Y, et al. Nat Commun. 2018 Dec 21;9(1):5435. doi: 10.1038/s41467-018-07825-3. Nat Commun. 2018. PMID: 30575733 Free PMC article.

7

Both perforin and FasL are required for optimal CD8 T cell control of autoreactive B cells and autoantibody production in parent-into-F1 lupus mice.

Soloviova K, Puliaiev M, Puliaev R, Puliaeva I, Via CS. Soloviova K, et al. Clin Immunol. 2018 Sep;194:34-42. doi: 10.1016/j.clim.2018.06.007. Epub 2018 Jun 22. Clin Immunol. 2018. PMID: 29940333 Free PMC article.

8

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I. Brennan AJ, et al. Cell Death Differ. 2018 Aug;25(8):1517-1529. doi: 10.1038/s41418-018-0057-z. Epub 2018 Feb 7. Cell Death Differ. 2018. PMID: 29416110 Free PMC article.

9

Antigen-specific CD8⁺ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.

Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y. Yao Y, et al. Nat Commun. 2017 May 24;8:15402. doi: 10.1038/ncomms15402. Nat Commun. 2017. PMID: 28537251 Free PMC article.

10

Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.

Huggins MA, Johnson HL, Jin F, N Songo A, Hanson LM, LaFrance SJ, Butler NS, Harty JT, Johnson AJ. Huggins MA, et al. Infect Immun. 2017 Apr 21;85(5):e00985-16. doi: 10.1128/IAI.00985-16. Print 2017 May. Infect Immun. 2017. PMID: 28264905 Free PMC article.

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